Banis Georgios, Tyrovolas Konstantinos, Angelopoulos Spyridon, Ferraro Angelo, Hristoforou Evangelos
Laboratory of Electronic Sensors, National TU of Athens, Zografou Campus, 15780 Athens, Greece.
Department of Metal Protection and Surface Treatment, National University of Science and Technology (MISiS), 119049 Moscow, Russia.
Nanomaterials (Basel). 2020 Feb 20;10(2):371. doi: 10.3390/nano10020371.
Treatment of certain diseases requires the administration of drugs at specific areas of tissues and/or organs to increase therapy effectiveness and avoid side effects that may harm the rest of the body. Drug targeting is a research field that uses various techniques to administrate therapies at specific areas of the body, including magnetic systems able to drive nano "vehicles", as well as magnetically labeled molecules, in human body fluids and tissues. Most available actuation systems can only attract magnetic elements in a relatively small workspace, limiting drug target applications to superficial tissues, and leaving no alternative cases where deep targeting is necessary. In this paper, we propose an electromagnetic actuation system able to push and deflect magnetic particles at distance of ~10 cm, enabling the manipulation of magnetic nano- and microparticles, as well as administration of drugs in tissues, which are not eligible for localized drug targeting with state-of-the-art systems. Laboratory experiments and modeling were conducted to prove the effectiveness of the proposed system. By further implementing our device, areas of the human body that previously were impossible to treat with magnetically labeled materials such as drugs, cells, and small molecules can now be accessible using the described system.
某些疾病的治疗需要在组织和/或器官的特定区域给药，以提高治疗效果并避免可能损害身体其他部位的副作用。药物靶向是一个研究领域，它使用各种技术在身体的特定区域进行治疗，包括能够在人体体液和组织中驱动纳米“载体”以及磁性标记分子的磁性系统。大多数现有的驱动系统只能在相对较小的工作空间内吸引磁性元件，这将药物靶向应用限制在浅表组织，并且没有其他需要深度靶向的替代情况。在本文中，我们提出了一种电磁驱动系统，该系统能够在约10厘米的距离推动和偏转磁性颗粒，从而能够操纵磁性纳米颗粒和微米颗粒，并在组织中给药，而这些组织无法通过现有技术进行局部药物靶向治疗。我们进行了实验室实验和建模，以证明所提出系统的有效性。通过进一步改进我们的设备，以前无法用磁性标记材料（如药物、细胞和小分子）治疗的人体区域现在可以使用所描述系统进行治疗。
