Mirmohammadi Mirtaghi, Ibrahim M Hakimi, Ahmad Anees, Kadir Mohd Omar Abdul, Mohammadyan M, Mirashrafi S B
School of Industrial Technology, University Science Malaysia, 11800, Pulau Pinang, Malaysia.
Indian J Occup Environ Med. 2009 Apr;13(1):38-42. doi: 10.4103/0019-5278.50723.
Today many raw materials used in factories may have a dangerous effect on the physiological system of workers. One of them, which is widely used in the polyurethane factories, is diisocyanates. These compounds are widely used in surface coatings, polyurethane foams, adhesives, resins, elastomers, binders, and sealants. Exposure to diisocyanates causes irritation to the skin, mucous membranes, eyes, and respiratory tract. Methylene dianiline (MDA) is a metabolite of methylene diphenyle diisocyanate (MDI), an excretory material of worker's urine who are exposed to MDI. Around 100 air samples were collected among five factories by the Midget Impinger, which contained DMSO absorbent as a solvent and Tryptamine as a reagent. Samples were analyzed by high-performance liquid chromatography with an EC\UV detector using the NIOSH 5522 method of sampling and analysis. Also, fifty urine samples were collected from workers by using William's biological analysis method. The concentration of MDI in all air samples was more than 88 mug/m(3), showing a high concentration of the pollutant in the workplaces in comparison with the NIOSH standard, and all the worker's urine was contaminated by MDA. The correlation and regression tests were used to obtain statistical model for MDI and MDA that is useful for prediction of diisocyanates pollution situation in the polyurethane factories.
如今，工厂使用的许多原材料可能会对工人的生理系统产生危险影响。其中之一是二异氰酸酯，它在聚氨酯工厂中被广泛使用。这些化合物广泛应用于表面涂料、聚氨酯泡沫、粘合剂、树脂、弹性体、粘合剂和密封剂中。接触二异氰酸酯会导致皮肤、粘膜、眼睛和呼吸道受到刺激。亚甲基二苯胺（MDA）是二苯基甲烷二异氰酸酯（MDI）的代谢产物，是接触MDI的工人尿液中的一种排泄物。通过小型冲击式采样器在五家工厂中采集了约100个空气样本，该采样器以二甲基亚砜作为溶剂，色胺作为试剂。采用NIOSH 5522采样和分析方法，使用电化学/紫外检测器的高效液相色谱法对样本进行分析。此外，还采用威廉姆斯生物分析法从工人那里采集了50份尿液样本。所有空气样本中MDI的浓度均超过88微克/立方米，与NIOSH标准相比，工作场所污染物浓度较高，并且所有工人的尿液都被MDA污染。使用相关性和回归测试来获得MDI和MDA的统计模型，该模型有助于预测聚氨酯工厂中二异氰酸酯的污染情况。
