School of Industrial Technology, University Science Malaysia, Pulau Pinang, Malaysia.
Environ Monit Assess. 2010 Jun;165(1-4):341-7. doi: 10.1007/s10661-009-0950-5. Epub 2009 May 15.
Today, many raw materials used in factories may have a dangerous effect on the physiological system of workers. One of them which is widely used in the polyurethane factories is diisocyanates. These compounds are widely used in surface coatings, polyurethane foams, adhesives, resins, elastomers, binders, and sealants. Exposure to diisocyanates causes irritation to the skin, mucous membranes, eyes, and respiratory tract. Hexamethylene diamine (HDA) is metabolite of hexamethylene diisocyanate (HDI). It is an excretory material by worker's urine who is exposed to HDI. Around 100 air samples were collected from five defined factories by midget impinger which contained dimethyl sulfoxide absorbent as a solvent and tryptamine as reagent. Samples were analyzed by high-performance liquid chromatography with EC\UV detector using NIOSH 5522 method of sampling. Also, 50 urine samples collected from workers were also analyzed using William's biological analysis method. The concentration of HDI into all air samples were more than 88 microg/m(3), and they have shown high concentration of pollutant in the workplaces in comparison with NIOSH standard, and all of the workers' urine were contaminated by HDA. The correlation and regression test were used to obtain statistical model for HDI and HDA, which is useful for the prediction of diisocyanates pollution situation in the polyurethane factories.
如今，许多工厂使用的原材料可能对工人的生理系统产生危险影响。其中一种在聚氨酯工厂中广泛使用的是异氰酸酯。这些化合物广泛用于表面涂料、聚氨酯泡沫、粘合剂、树脂、弹性体、胶粘剂和密封剂。接触异氰酸酯会刺激皮肤、粘膜、眼睛和呼吸道。己二胺（HDA）是己二异氰酸酯（HDI）的代谢物。它是接触 HDI 的工人尿液中的排泄物质。通过微型冲击器从五个指定工厂收集了约 100 个空气样本，其中含有二甲基亚砜作为溶剂和色胺作为试剂。使用 NIOSH 5522 采样方法通过高效液相色谱法与 EC\UV 检测器对样品进行分析。此外，还使用威廉姆斯生物分析方法对 50 名工人的尿液样本进行了分析。所有空气样本中 HDI 的浓度均超过 88 微克/立方米，与 NIOSH 标准相比，它们显示出工作场所中污染物的浓度较高，并且所有工人的尿液都受到 HDA 的污染。使用相关和回归测试获得了用于预测聚氨酯工厂中二异氰酸酯污染情况的 HDI 和 HDA 的统计模型。
