巨噬细胞移动抑制因子：在肥胖、胰岛素抵抗及相关合并症中的关键作用。
Macrophage migration inhibitory factor: critical role in obesity, insulin resistance, and associated comorbidities.
机构信息
Department of Biosciences, Gaubius Laboratory, TNO-Quality of Life, Zernikedreef 9, 2301 CE Leiden, The Netherlands.
出版信息
Mediators Inflamm. 2010;2010:610479. doi: 10.1155/2010/610479. Epub 2010 Feb 9.
Abstract
Obesity is associated with insulin resistance, disturbed glucose homeostasis, low grade inflammation, and comorbidities such as type 2 diabetes and cardiovascular disease. The cytokine macrophage migration inhibitory factor (MIF) is an ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders. Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity. This is a comprehensive summary of our current knowledge on the role of MIF in obesity and obesity-associated comorbidities, based on human clinical data as well as animal models of disease.
摘要
肥胖与胰岛素抵抗、葡萄糖稳态紊乱、低度炎症以及 2 型糖尿病和心血管疾病等合并症有关。细胞因子巨噬细胞移动抑制因子（MIF）是一种广泛表达的蛋白质，在许多炎症和自身免疫性疾病中发挥着关键作用。越来越多的证据表明，MIF 还控制着代谢和炎症过程，这些过程是与肥胖相关的代谢性疾病发展的基础。这是基于人类临床数据和疾病动物模型，对 MIF 在肥胖和肥胖相关合并症中的作用的全面总结。
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