Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, USA.
J Org Chem. 2010 Mar 19;75(6):2044-9. doi: 10.1021/jo100102a.
A divergent fluorous mixture synthesis (FMS) of asymmetric fluorinated dendrimers has been developed. Four generations of fluorinated dendrimers with the same fluorinated moiety were prepared with high efficiency, yield, and purity. Comparison of the physicochemical properties of these dendrimers provided valuable information for their application and future optimization. This strategy has not only provided a practical method for the synthesis and purification of dendrimers, but also established the possibility of utilizing the same fluorinated moiety for FMS.
已开发出一种不对称氟化树枝状大分子的发散氟混合物合成（FMS）方法。采用高效率、高产率和高纯度制备了具有相同氟化部分的四代氟化树枝状大分子。对这些树枝状大分子的物理化学性质进行比较，为它们的应用和未来的优化提供了有价值的信息。该策略不仅为树枝状大分子的合成和纯化提供了一种实用的方法，而且还为利用相同的氟化部分进行 FMS 提供了可能性。
