Hashemi Mohammad, Kelishadi Roya, Hashemipour Mahin, Zakerameli Afshin, Khavarian Noushin, Ghatrehsamani Shohreh, Poursafa Parinaz
Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Cardiol Young. 2010 Feb;20(1):73-7. doi: 10.1017/S1047951109990850. Epub 2010 Feb 22.
This study, which to the best of our knowledge is the first of its kind, aimed to determine the acute and long-term effects of the consumption of grape and pomegranate juices on endothelium function in adolescents with metabolic syndrome, and to compare the effects of these two kinds of juices.
This randomised controlled clinical trial was conducted in 2008 among 30 adolescents, aged 12-15 years, with metabolic syndrome. Participants were randomly assigned to two groups of equal number; one group was asked to drink 18 millilitre per kilogram per day of natural grape juice and the other group was asked to drink 240 millilitre per day of natural pomegranate juice once daily for 1 month. Juices were homemade without any added sweetener. Basal brachial artery dimension and flow-mediated dilation as an index of endothelial function and endothelial-dependent dilation after receiving nitoglycerin spray were evaluated by high-resolution B mode ultrasonography before juice consumption, 4 hours and 30 days after regular daily consumption.
Flow-mediated dilation at 90 seconds and after nitoglycerin significantly improved at 4 hours and at 1 month after drinking both kinds of juices, without significant difference between the two groups. The change at 1 month versus 4 hours was significant only in the grape juice group.
Daily consumption of diets rich in antioxidants might improve endothelial function in adolescents with metabolic syndrome. These effects began as soon as 4 hours after juice consumption. Such beneficial effects should be considered in dietary recommendations for the paediatric age group, notably in obese individuals.
据我们所知，本研究首次旨在确定饮用葡萄汁和石榴汁对患有代谢综合征的青少年内皮功能的急性和长期影响，并比较这两种果汁的效果。
2008年，对30名年龄在12 - 15岁的患有代谢综合征的青少年进行了这项随机对照临床试验。参与者被随机分为两组，每组人数相等；一组被要求每天每公斤饮用18毫升天然葡萄汁，另一组被要求每天饮用240毫升天然石榴汁，每天一次，持续1个月。果汁均为自制，未添加任何甜味剂。在饮用果汁前、每天规律饮用4小时和30天后，通过高分辨率B型超声评估肱动脉基础尺寸以及作为内皮功能指标的血流介导的舒张和接受硝酸甘油喷雾后的内皮依赖性舒张。
饮用两种果汁后4小时和1个月时，90秒时的血流介导的舒张以及硝酸甘油后的血流介导的舒张均显著改善，两组之间无显著差异。仅葡萄汁组1个月时与4小时时的变化具有显著性。
每日食用富含抗氧化剂的饮食可能改善患有代谢综合征的青少年的内皮功能。这些效果在饮用果汁后4小时就开始显现。在针对儿童年龄组，尤其是肥胖个体的饮食建议中应考虑到这种有益效果。
