Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Athens, Greece.
Nutr Metab Cardiovasc Dis. 2011 Aug;21(8):561-7. doi: 10.1016/j.numecd.2009.11.005. Epub 2010 Feb 19.
Elevated dietary antioxidant activity has been regarded as providing potential benefits to health. The present work aimed at evaluating the association of glycemic indices with total dietary antioxidant capacity in healthy adults.
The ATTICA study consisted of men and women, randomly selected from all areas of Attica region in Greece. In this work, a random sub-sample from the ATTICA study's database was studied, consisting of 551 men (41 ± 11 years) and 467 women (38 ± 11 years), with complete nutritional and biochemical information. Dietary habits were evaluated using a validated food-frequency questionnaire. The dietary antioxidant capacity was based on published values for Italian foods measured by three different assays: ferric-reducing antioxidant power (FRAP), total radical-trapping antioxidant parameter (TRAP) and Trolox equivalent antioxidant capacity (TEAC). Inverse, age-energy adjusted correlations were observed between FRAP and log-glucose (r = -0.149, p = 0.001), log-insulin (r = -0.221, p = 0.001) and log-HOMA-IR (r = -0.186, p = 0.001) concentration, as well as with TRAP and TEAC. After controlling for age, gender, body mass index, physical activity status, smoking habits and energy intake, multi-adjusted analysis confirmed the previous relationships only among participants who were not on the Mediterranean dietary pattern.
Although more prospective studies are required, the data presented support the view that dietary modification towards higher consumption of antioxidants should be implemented in public health strategies, in order to better control glycemic markers in individuals, and prevent the development of diabetes at the population level.
提高膳食抗氧化活性被认为对健康有益。本研究旨在评估健康成年人的血糖指数与总膳食抗氧化能力之间的关系。
ATTICA 研究包括来自希腊雅典地区各个地区的男性和女性，随机选择。在这项工作中，从 ATTICA 研究数据库中随机抽取了一个子样本，包括 551 名男性（41±11 岁）和 467 名女性（38±11 岁），他们的营养和生化信息完整。通过验证的食物频率问卷评估饮食习惯。膳食抗氧化能力基于发表的意大利食物值，使用三种不同的测定法进行测量：铁还原抗氧化能力（FRAP）、总自由基捕获抗氧化参数（TRAP）和 Trolox 等效抗氧化能力（TEAC）。FRAP 与 log-葡萄糖（r=-0.149，p=0.001）、log-胰岛素（r=-0.221，p=0.001）和 log-HOMA-IR（r=-0.186，p=0.001）浓度呈反向、年龄能量调整相关，TRAP 和 TEAC 也是如此。在校正年龄、性别、体重指数、身体活动状况、吸烟习惯和能量摄入后，多因素分析仅在未遵循地中海饮食模式的参与者中证实了上述关系。
尽管需要更多的前瞻性研究，但目前的数据支持这样一种观点，即应在公共卫生策略中实施膳食抗氧化剂的调整，以更好地控制个体的血糖标志物，并防止人群层面糖尿病的发生。
