慢性丙型病毒性肝炎患者接受干扰素-α和利巴韦林治疗的眼内并发症
Intraocular complications of IFN-alpha and ribavirin therapy in patients with chronic viral hepatitis C.
作者信息
Sene Damien, Touitou Valerie, Bodaghi Bahram, Saadoun David, Perlemuter Gabriel, Cassoux Nathalie, Piette Jean-Charles, Hoang Phuc-Le, Cacoub Patrice
机构信息
Department of Internal Medicine, Hôpital Pitié-Salpêtrière, Paris, France.
出版信息
World J Gastroenterol. 2007 Jun 14;13(22):3137-40. doi: 10.3748/wjg.v13.i22.3137.
Abstract
We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha (IFN-alpha) treatment in eight hepatitis C virus (HCV)-infected patients. These events include three cases of Vogt-Koyanagi-Harada like (VKH) disease (an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes), two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-alpha treatment with ophthalmological monitoring if any ocular manifestation occurs.
摘要
我们报告了8例丙型肝炎病毒（HCV）感染患者在接受α干扰素（IFN-α）治疗期间发生的一系列严重的炎症性和血管性眼内疾病。这些事件包括3例Vogt-小柳原田样（VKH）病（一种伴有全葡萄膜炎、视网膜脱离、耳部和脑膜病变以及皮肤和毛发改变的综合征）、2例视网膜中央静脉阻塞、1例视网膜中央动脉阻塞、1例严重高血压性视网膜病变以及1例伴有严重视力损害的双侧缺血性视神经病变。尽管这些严重的眼科并发症很罕见，但对于接受IFN-α治疗的HCV感染患者，如果出现任何眼部表现，都需要密切随访并进行眼科监测。
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