Università degli Studi di Milano, IRCCS Fondazione Policlinico, Mangiagalli, Regina Elena, Dipartimento di Scienze Mediche, Gastroenterologia 3, Milano, Italy.
Eur J Gastroenterol Hepatol. 2010 Nov;22(11):1380-6. doi: 10.1097/MEG.0b013e3283352ced.
Data about small bowel capsule endoscopy (SBCE) come from studies involving small and highly selected populations. The study aim was to describe extent of use, indications, results, complications, and practical issues of SBCE in clinical practice in a Northern Italian Region (Lombardia).
Twenty-three out of 29 invited centers fulfilled a specific questionnaire.
Between 2001 and 2008, 2921 procedures were performed and both the number of centers performing SBCE (from 5 to 29) and the number of SBCE (from 7.2 to 69.2 per month) increased steadily. The main indications for SBCE were: obscure gastrointestinal bleeding (OGIB) (43.4%), unexplained anemia (23.9%), suspected Crohn's disease (7.8%) and abdominal pain (5.3%). Overall, SBCE was positive in 50% of cases, negative in 36% and undefined in 14%. The highest diagnostic yields were observed in patients with OGIB (62.5%), polypoid syndromes (74.1%), known (54.8%) or suspected (47.3%) inflammatory bowel disease, while the yields were low in patients examined for chronic diarrhea (27.4%) and abdominal pain (14.9%), 61 patients (2.1%) experienced capsule retention. Thirty-two of them eventually excreted the capsule naturally while endoscopic or surgical retrieval was necessary in 29 (1%) (in two because of obstruction).
Over a period of 7 years the use of SBCE in Lombardia increased steadily confirming, in clinical practice, a high diagnostic yield and an acceptable safety profile.
小肠胶囊内镜（SBCE）的数据来自涉及小范围且高度选择人群的研究。本研究旨在描述在意大利北部伦巴第地区（Lombardia）的临床实践中 SBCE 的使用程度、适应证、结果、并发症和实际问题。
29 家受邀中心中的 23 家完成了一份特定的问卷。
在 2001 年至 2008 年间，共进行了 2921 例检查，实施 SBCE 的中心数量（从 5 家增至 29 家）和 SBCE 例数（从每月 7.2 例增至 69.2 例）均稳步增加。SBCE 的主要适应证为：不明原因的胃肠道出血（OGIB）（43.4%）、不明原因的贫血（23.9%）、疑诊克罗恩病（7.8%）和腹痛（5.3%）。总体而言，SBCE 阳性率为 50%，阴性率为 36%，无法确定率为 14%。OGIB（62.5%）、息肉综合征（74.1%）、已知（54.8%）或疑诊（47.3%）炎症性肠病患者的诊断率最高，而慢性腹泻（27.4%）和腹痛（14.9%）患者的诊断率较低。61 例（2.1%）患者出现胶囊滞留。其中 32 例最终自然排出胶囊，29 例（1%）需行内镜或手术取出（2 例因梗阻）。
在 7 年的时间里，伦巴第地区 SBCE 的使用稳步增加，这在临床实践中证实了其具有较高的诊断率和可接受的安全性。
