Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Tunisia.
J Renin Angiotensin Aldosterone Syst. 2010 Sep;11(3):180-6. doi: 10.1177/1470320309360816. Epub 2010 Feb 22.
We investigated the contribution of aldosterone synthase CYP11B2 polymorphism (C-344T) to the age-related changes in blood pressure in stroke patients.
Study subjects comprised 329 stroke patients (121 normotensive, 208 hypertensive) and 444 healthy controls. Genotyping was done by PCR-RFLP, and the contribution of CYP11B2 polymorphism to the risk of stroke was analysed by regression analysis.
The T allele, and CT, TT, and CT + TT genotypes, independently of sex and age, were significantly associated with increased stroke risk. Varied distributions of CYP11B2 genotypes were noted among patients with respect to gender, age and hypertension status, being pronounced in hypertensive patients. Both systolic and diastolic blood pressure were positively correlated with the presence of T allele. Mean systolic and diastolic blood pressure were significantly higher among young (< 60 years) CT and TT genotype carriers. Regression analysis confirmed the positive association of CT and TT genotypes and systolic blood pressure, and the negative association of diastolic blood pressure with odds of stroke development. Taking normotensive patients as reference, regression analysis identified TT genotype, age and female gender to be independently associated with increased odds of stroke.
Compared to CC genotype, CT and TT CYP11B2 genotypes are independently associated with increased stroke index.
我们研究了醛固酮合酶 CYP11B2 多态性（C-344T）对中风患者血压与年龄相关变化的影响。
研究对象包括 329 名中风患者（121 名血压正常，208 名高血压）和 444 名健康对照者。采用 PCR-RFLP 进行基因分型，并通过回归分析研究 CYP11B2 多态性对中风风险的影响。
T 等位基因，以及 CT、TT 和 CT+TT 基因型，与独立于性别和年龄的中风风险增加显著相关。CYP11B2 基因型在患者中的分布因性别、年龄和高血压状态而异，在高血压患者中更为明显。收缩压和舒张压均与 T 等位基因的存在呈正相关。收缩压和舒张压在年轻（<60 岁）CT 和 TT 基因型携带者中显著升高。回归分析证实 CT 和 TT 基因型与收缩压呈正相关，与舒张压呈负相关，与中风发生的几率呈正相关。以血压正常的患者为参照，回归分析确定 TT 基因型、年龄和女性是与中风风险增加独立相关的因素。
与 CC 基因型相比，CT 和 TT CYP11B2 基因型与中风指数增加独立相关。
