基于离子浓差极化的生物分子纳流控浓缩装置：理论、制造与应用。
Nanofluidic concentration devices for biomolecules utilizing ion concentration polarization: theory, fabrication, and applications.
机构信息
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
出版信息
Chem Soc Rev. 2010 Mar;39(3):912-22. doi: 10.1039/b822556g. Epub 2010 Jan 4.
Abstract
Recently, a new type of electrokinetic concentration devices has been developed in a microfluidic chip format, which allows efficient trapping and concentration of biomolecules by utilizing ion concentration polarization near nanofluidic structures. These devices have drawn much attention not only due to their potential application in biomolecule sensing, but also due to the rich scientific content related to ion concentration polarization, the underlying physical phenomenon for the operation of these electrokinetic concentration devices. This tutorial review provides an introduction to the scientific and engineering advances achieved, in-depth discussion about several interesting applications of these unique concentration devices, and their current limitations and challenges.
摘要
最近，一种新型的电泳浓缩设备以微流控芯片的形式被开发出来，它通过利用纳米流道结构附近的离子浓度极化，实现了生物分子的高效捕获和浓缩。这些设备不仅因为在生物分子传感方面的潜在应用而受到关注，还因为与离子浓度极化相关的丰富科学内容，这是这些电泳浓缩设备运行的基础物理现象。本教程综述介绍了所取得的科学和工程进展，深入讨论了这些独特浓缩设备的一些有趣应用及其当前的局限性和挑战。
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