一名原发性血小板增多症患者出现那屈肝素诱导的皮肤坏死：病例报告

Pramateftakis Manousos-Georgios, Kanellos Dimitrios, Psomas Stefanos, Kanellos Ioannis

Department of Surgery, European Medical Center, Asklipiou 10, 57001 Thessaloniki, Greece.

Cases J. 2009 Mar 10;2:6458. doi: 10.1186/1757-1626-0002-0000006458.

Skin necrosis is a rare but serious complication of subcutaneously administered low-molecular-weight heparin. We report a case of a 53-year-old female patient with skin necrosis induced by subcutaneous administration of nadroparine. The patient suffered from essential thrombocythaemia on a background of chronic myeloproliferative disease. She was admitted to our clinic with a subacute ileus due to endometriosis of the rectosigmoid junction. She underwent a high anterior resection and she received pre- and postoperative antithrombotic prophylaxis with subcutaneous nadroparine on a daily basis. On the 6th and 7th postoperative days, two skin necroses occurred at two injection sites.

皮肤坏死是皮下注射低分子量肝素罕见但严重的并发症。我们报告一例53岁女性患者，因皮下注射那屈肝素诱导皮肤坏死。该患者在慢性骨髓增殖性疾病背景下患有原发性血小板增多症。她因直肠乙状结肠交界处子宫内膜异位症伴亚急性肠梗阻入住我院。她接受了前切除术，并在术前和术后每日皮下注射那屈肝素进行抗血栓预防。术后第6天和第7天，两个注射部位出现了两处皮肤坏死。