摄入甘草后出现的低钾性肌无力：一例报告。
A hypokalemic muscular weakness after licorice ingestion: a case report.
作者信息
Meltem Akkas Camkurt, Figen Coskun, Nalan Metin Aksu, Mahir Kunt, Sebnem Bozkurt, Mehlika Isildak, Kasim Kilic Ahmet, Miyase Bayraktar
机构信息
Department of Emergency, Hacettepe University, Sihhiye Ankara, Turkey.
出版信息
Cases J. 2009 Sep 17;2:8053. doi: 10.1186/1757-1626-0002-0000008053.
Abstract
A 21-year-old male presented to the emergency department with the complaint of muscle weakness. The patient had used a powderized over-the-counter product named 'Tekumut' for 2 weeks to quit smoking. The granulated product was studied and determined to contain 'licorice' containing glycyrrhizic acid.Licorice (a plant which contain glycyrrhizic acid) -induced hypokalemia usually has a mild progression. However, it may cause a critical failure in physical action by means of weakness followed by paralysis and may cause rhabdomyolysis or ventricular fibrillation, leading to death, when left untreated.This report has presented the first case with hypocalemia due to licorice consumption in granulated form from Turkey. In addition, the report has aimed to emphasize the importance of obtaining the detailed history of a patient in diagnosis.
摘要
一名21岁男性因肌肉无力主诉前往急诊科就诊。该患者使用一种名为“Tekumut”的非处方粉末状产品戒烟达2周。对该颗粒状产品进行研究后确定其含有含甘草酸的“甘草”。甘草（一种含甘草酸的植物）所致低钾血症通常进展较为缓慢。然而，它可能会通过肌无力继而发展为麻痹导致身体活动严重障碍，若不治疗，还可能引发横纹肌溶解或室颤，进而导致死亡。本报告呈现了土耳其首例因食用颗粒状甘草而导致低钙血症的病例。此外，该报告旨在强调在诊断过程中获取患者详细病史的重要性。
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本文引用的文献
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Intern Med. 2007;46(9):575-8. doi: 10.2169/internalmedicine.46.6316. Epub 2007 May 1.
2
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Life Sci. 2007 Apr 3;80(17):1545-52. doi: 10.1016/j.lfs.2007.01.033. Epub 2007 Jan 27.
3
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Int J Cardiol. 2008 Mar 14;124(3):e42-4. doi: 10.1016/j.ijcard.2006.11.190. Epub 2007 Feb 22.
4
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