Nunes E V, Quitkin F M, Brady R, Stewart J W
Depression Evaluation Service, New York State Psychiatric Institute, NY 10032.
Am J Psychiatry. 1991 May;148(5):667-9. doi: 10.1176/ajp.148.5.667.
Of 17 consecutive patients receiving methadone maintenance treatment who had primary or chronic depression, nine (53%) improved in both mood and drug abuse after imipramine treatment. This finding suggests a potential for helping such dual-diagnosis patients reduce drug abuse and associated risk for HIV. Further controlled trials are warranted.
在17名接受美沙酮维持治疗且患有原发性或慢性抑郁症的连续患者中，9名（53%）在接受丙咪嗪治疗后情绪和药物滥用情况均有所改善。这一发现表明，有可能帮助此类双重诊断患者减少药物滥用及相关的艾滋病毒感染风险。有必要进行进一步的对照试验。
