Orthopaedic Trauma, McGill University, Montreal, Quebec, Canada.
J Orthop Trauma. 2010 Mar;24 Suppl 1:S25-30. doi: 10.1097/BOT.0b013e3181ca3b58.
Nanotechnology and its attendant techniques have yet to make a significant impact on the science of bone healing. However, the potential benefits are immediately obvious with the result that hundreds of researchers and firms are performing the basic research needed to mature this nascent, yet soon to be fruitful niche. Together with genomics and proteomics, and combined with tissue engineering, this is the new face of orthopaedic technology. The concepts that orthopaedic surgeons recognize are fabrication processes that have resulted in porous implant substrates as bone defect augmentation and medication-carrier devices. However, there are dozens of applications in orthopaedic traumatology and bone healing for nanometer-sized entities, structures, surfaces, and devices with characteristic lengths ranging from 10s of nanometers to a few micrometers. Examples include scaffolds, delivery mechanisms, controlled modification of surface topography and composition, and biomicroelectromechanical systems. We review the basic science, clinical implications, and early applications of the nanotechnology revolution and emphasize the rich possibilities that exist at the crossover region between micro- and nanotechnology for developing new treatments for bone healing.
纳米技术及其相关技术尚未对骨愈合科学产生重大影响。然而，其潜在的益处是显而易见的，结果是数以百计的研究人员和公司正在进行基础研究，以使这一新兴但即将硕果累累的领域成熟。与基因组学和蛋白质组学相结合，并与组织工程相结合，这是矫形技术的新面貌。矫形外科医生所认识的概念是制造工艺，这些工艺导致了多孔植入物基质作为骨缺损增强和药物载体装置。然而，在骨科创伤学和骨愈合方面，有数十种应用涉及到纳米级实体、结构、表面和具有特征长度从数十纳米到几微米的设备。例如，支架、输送机制、表面形貌和组成的控制修饰以及生物微电子机械系统。我们回顾了纳米技术革命的基础科学、临床意义和早期应用，并强调了微纳技术交叉区域为骨愈合新疗法的发展所存在的丰富可能性。
