Department of Gastroenterology, Fatih University Medical School - Ankara, Turkey.
Clinics (Sao Paulo). 2010 Feb;65(2):221-31. doi: 10.1590/S1807-59322010000200015.
The inflammatory bowel diseases, consisting of Crohn's disease, ulcerative colitis and indeterminate colitis, are distinguished by idiopathic and chronic inflammation of the digestive tract. The distinction between inflammatory bowel diseases and functional bowel disorders, such as irritable bowel syndrome, can be complex because they often present with similar symptoms. Rapid and inexpensive noninvasive tests that are sensitive, specific and simple are needed to prevent patient discomfort, delay in diagnosis, and unnecessary costs. None of the current commercially available serological biomarker tests can be used as a stand-alone diagnostic in clinics. Instead, these are used as an adjunct to endoscopy in diagnosis and prognosis of the disease. Along these lines,, fecal lactoferrin and calprotectin tests seem to be one step further from other tests with larger number of studies, higher sensitivity and specificity and wider availability.
炎症性肠病包括克罗恩病、溃疡性结肠炎和未定型结肠炎，其特征为消化道的特发性和慢性炎症。炎症性肠病和功能性肠病（如肠易激综合征）之间的区别可能很复杂，因为它们通常表现出相似的症状。需要快速、廉价、非侵入性、敏感、特异和简单的检测方法，以防止患者不适、诊断延误和不必要的费用。目前市售的任何一种血清生物标志物检测都不能单独作为临床诊断。相反，这些检测通常在内镜检查中作为辅助手段，用于疾病的诊断和预后。在这方面，粪便乳铁蛋白和钙卫蛋白检测似乎比其他检测更进一步，这些检测有更多的研究、更高的敏感性和特异性以及更广泛的可用性。
