Division of Respirology, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Can Respir J. 2010 Jan-Feb;17(1):e14-9. doi: 10.1155/2010/142031.
Supplemental oxygen therapy has been shown to improve exercise performance in patients with chronic obstructive pulmonary disease (COPD). It is unknown whether the magnitude of this benefit would be affected by participation in a pulmonary rehabilitation program.
To compare the effects of supplemental oxygen on exercise capacity in nonhypoxemic COPD patients before and after participation in a pulmonary rehabilitation program.
Sixteen patients with COPD underwent two pairs of constant-load exercise tests before and after participation in a three-month outpatient pulmonary rehabilitation program. Each pair of exercise tests consisted of a test performed with room air and a second test performed with 50% supplemental oxygen, in random order. The primary outcome was the difference in exercise duration between tests performed with supplemental oxygen and with room air. This difference was compared before and after participation in a pulmonary rehabilitation program.
Supplemental oxygen therapy improved exercise duration by 75 s before participation in a pulmonary rehabilitation program and by 153 s following pulmonary rehabilitation. Rehabilitation alone improved exercise duration by 28 s, but rehabilitation appeared to augment the exercise benefits of supplemental oxygen therapy by a mean of 78 s (95% CI 11 s to 145 s; P = 0.03).
The effects of supplemental oxygen therapy were augmented after pulmonary rehabilitation. The improvement in exercise duration with supplemental oxygen following rehabilitation was greater than either supplemental oxygen or pulmonary rehabilitation alone.
补充氧气疗法已被证明可改善慢性阻塞性肺疾病（COPD）患者的运动表现。但目前尚不清楚这种益处的程度是否会受到参与肺康复计划的影响。
比较非低氧血症 COPD 患者在参与肺康复计划前后补充氧气对运动能力的影响。
16 名 COPD 患者在参加为期三个月的门诊肺康复计划前后进行了两组恒负荷运动测试。每对运动测试均由在空气和 50%补充氧气下进行的两项测试组成，随机进行。主要结局是在补充氧气和空气下进行的测试之间的运动时间差异。在参加肺康复计划前后对其进行了比较。
在参加肺康复计划之前，补充氧气疗法可将运动时间延长 75 秒，而在参加肺康复计划之后则可延长 153 秒。单独的康复可使运动时间延长 28 秒，但康复似乎平均可使补充氧气疗法的运动益处增加 78 秒（95%CI 11 秒至 145 秒；P=0.03）。
肺康复后补充氧气疗法的效果增强。康复后补充氧气的运动时间延长大于补充氧气或肺康复单独使用的效果。
