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有丝分裂中期微管星状体是果蝇神经母细胞不对称分裂方向的决定因素。

The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts.

机构信息

Cell Division Group, Institute for Research in Biomedicine Barcelona, 08028 Barcelona, Spain.

出版信息

J Cell Biol. 2010 Mar 8;188(5):693-706. doi: 10.1083/jcb.200905024. Epub 2010 Mar 1.

DOI:10.1083/jcb.200905024
PMID:20194641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2835941/
Abstract

The mechanisms that maintain the orientation of cortical polarity and asymmetric division unchanged in consecutive mitoses in Drosophila melanogaster neuroblasts (NBs) are unknown. By studying the effect of transient microtubule depolymerization and centrosome mutant conditions, we have found that such orientation memory requires both the centrosome-organized interphase aster and centrosome-independent functions. We have also found that the span of such memory is limited to the last mitosis. Furthermore, the orientation of the NB axis of polarity can be reset to any angle with respect to the surrounding tissue and is, therefore, cell autonomous.

摘要

在果蝇神经母细胞（NB）的连续有丝分裂中，维持皮质极性和不对称分裂方向不变的机制尚不清楚。通过研究短暂的微管去聚合和中心体突变条件的影响，我们发现这种定向记忆需要中心体组织的有丝分裂前期星体和中心体独立的功能。我们还发现，这种记忆的持续时间有限，仅限于最后一次有丝分裂。此外，NB 极性轴的方向可以相对于周围组织重置为任意角度，因此是细胞自主的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/886b003d1c69/JCB_200905024_RGB_Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/b0ba63d748d6/JCB_200905024_RGB_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/85eea551084f/JCB_200905024_RGB_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/9ea4d50031c5/JCB_200905024_RGB_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/2bf6f9c4db90/JCB_200905024R_RGB_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/bd5ac7670b8d/JCB_200905024_RGB_Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/df226e5c4f18/JCB_200905024_RGB_Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/886b003d1c69/JCB_200905024_RGB_Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/b0ba63d748d6/JCB_200905024_RGB_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/85eea551084f/JCB_200905024_RGB_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/9ea4d50031c5/JCB_200905024_RGB_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/2bf6f9c4db90/JCB_200905024R_RGB_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/bd5ac7670b8d/JCB_200905024_RGB_Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/df226e5c4f18/JCB_200905024_RGB_Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/2835941/886b003d1c69/JCB_200905024_RGB_Fig7.jpg

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