Department of Pharmaceutics, University Of Minnesota, Minneapolis, Minnesota, USA.
Pharm Res. 2010 May;27(5):855-65. doi: 10.1007/s11095-010-0078-x. Epub 2010 Mar 3.
The deposition of magnetic particles was examined for the possibility of further enhancing the selectivity of inhalation drug administration for the treatment of lung cancer.
Superparamagnetic magnetite nanoparticles were prepared and ultrasonically atomized, dried, and passed through glass tubes in the presence and absence of a wedge-shaped permanent magnet. The change in the outlet aerosol size distribution due to magnetic deposition under various well-defined aerodynamic conditions and a measured magnetic field was determined by an aerodynamic particle sizer. In addition, computational fluid dynamics (CFD) simulations of magnetic aerosol transport and deposition were conducted.
The deposition fraction increased nearly linearly with particle diameter and was greater with lower air flow rates. The effect of tube diameter was complicated but well described by CFD simulations, as was the effect of particle size and air flow rate.
The descriptive power of CFD simulations was demonstrated in the in vitro deposition of magnetic aerosol particles. This suggests that CFD simulations can potentially be used in future studies to design systems for selective drug delivery in vivo as a function of magnetic properties, aerosol characteristics, and respiratory physiology.
研究磁性颗粒的沉积是否有可能进一步提高吸入式药物治疗肺癌的选择性。
制备超顺磁磁铁矿纳米颗粒，并进行超声雾化、干燥，然后在楔形永磁铁存在和不存在的情况下通过玻璃管。在各种明确定义的空气动力学条件和测量的磁场下，通过空气动力学颗粒尺寸分析仪确定磁性沉积导致的出口气溶胶粒度分布的变化。此外，还进行了磁性气溶胶传输和沉积的计算流体动力学 (CFD) 模拟。
沉积分数随粒径几乎呈线性增加，空气流速越低沉积分数越大。管直径的影响很复杂，但通过 CFD 模拟得到了很好的描述，颗粒大小和空气流速的影响也是如此。
CFD 模拟在磁性气溶胶颗粒的体外沉积中表现出很强的描述能力。这表明 CFD 模拟可能在未来的研究中用于设计根据磁性特性、气溶胶特性和呼吸生理学在体内进行选择性药物输送的系统。
