转变范式：用于传染病诊断的宿主基因特征
Shifting the paradigm: host gene signatures for diagnosis of infectious diseases.
作者信息
Ramilo Octavio, Mejías Asunción
机构信息
Division of Pediatric Infectious Diseases, Nationwide Children's Hospital and the Ohio State University College of Medicine, Columbus, OH 43205, USA.
出版信息
Cell Host Microbe. 2009 Sep 17;6(3):199-200. doi: 10.1016/j.chom.2009.08.007.
PMID:19748461
Abstract
Instead of focusing on the pathogen, in a paradigm shift, Zaas et al. (2009) identified host gene profiles as a strategy for diagnosis of respiratory infections. Application of host gene profiles offers tremendous possibilities for identification of diagnostic signatures, markers of disease severity, and eventually, prognostic indicators in the clinical setting.
摘要
与专注于病原体不同，在一次范式转变中，扎斯等人（2009年）将宿主基因谱确定为诊断呼吸道感染的一种策略。宿主基因谱的应用为识别诊断特征、疾病严重程度标志物以及最终在临床环境中的预后指标提供了巨大的可能性。
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