Department of Medical Microbiology, Chalubinskiego 5, 02-004 Warsaw, Medical University of Warsaw, Poland.
Mini Rev Med Chem. 2009 Nov 1;9(13):1527-37. doi: 10.2174/138955709790361557.
Beta-lactams are the most frequently used antimicrobials in combating infections. In the case of gram-positive bacteria resistant to beta-lactams, glycopeptides are the first choice. The occurrence, mechanisms and genetic background of the resistance of pathogenic staphylococci, streptococci and enterococci to beta-lactam and glycopeptide antibiotics were discussed. The resistances to well-established antimicrobials, as well as new agents (ceftobiprole, oritavancin, telavancin, dalbavancin) were taken into consideration in the text.
β-内酰胺类抗生素是抗感染治疗中最常用的抗菌药物。对于耐β-内酰胺类抗生素的革兰阳性菌，糖肽类抗生素是首选药物。本文讨论了致病性葡萄球菌、链球菌和肠球菌对β-内酰胺类和糖肽类抗生素产生耐药性的发生、机制和遗传背景。文中还考虑了对现有抗菌药物以及新型药物（头孢洛林、奥他万古、替拉万星、达巴万星）的耐药性。
