Logan Sa, Rajan Ms, Graham E, Johnson Em, Klein Jl
Departments of Infection, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.
Cases J. 2010 Jan 18;3:31. doi: 10.1186/1757-1626-3-31.
There are very few reports of Aspergillus fumigatus causing endogenous endophthalmitis (EAE) in immunocompetent individuals although it is well recognised in the immunocompromised. Treatment can be with intravitreal, intravenous and oral antifungal agents. The benefit of an oral agent is clear however the concentration of voriconazole in the inflamed eye after oral administration has not previously been documented.
We present a case of EAE in an immunocompetent 78-year-old Caucasian female who was subsequently managed with oral voriconazole. Using a bioassay, we show an appropriate voriconazole concentration in serum and vitreous samples.
This case adds to the limited literature on the prevalence of endogenous endophthalmitis in immunocompetent patients and supports the use of voriconazole in such cases.
尽管烟曲霉在免疫功能低下者中引起内源性眼内炎（EAE）已得到充分认识，但在免疫功能正常个体中导致EAE的报道非常少。治疗可采用玻璃体内、静脉内和口服抗真菌药物。口服药物的益处是明确的，然而口服伏立康唑后炎症眼中的药物浓度此前尚未有文献记载。
我们报告一例78岁免疫功能正常的白种女性发生EAE的病例，该患者随后接受口服伏立康唑治疗。通过生物测定，我们显示血清和玻璃体样本中伏立康唑浓度适宜。
该病例补充了免疫功能正常患者中内源性眼内炎患病率的有限文献，并支持在此类病例中使用伏立康唑。
