Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Finland.
Prostaglandins Leukot Essent Fatty Acids. 2010 Jul;83(1):45-54. doi: 10.1016/j.plefa.2010.02.001. Epub 2010 Mar 4.
The effects of canola-type rapeseed oil (RSO) on serum lipids, plasma fibrinogen, lipid oxidation and fatty acids were studied in three groups of subjects, two of which had not been consuming fish in their habitual diets. Forty-two volunteers (35 women, 7 men, 16-62 years) replaced fat with RSO for 6 weeks in a parallel design. The average cholesterol and fibrinogen concentrations were 5.0 mmol/l and 2.6 g/l, respectively. The intake of alpha-linolenic acid (alpha-LLA) was doubled. Efficient competitive inhibition by alpha-LLA was seen as a decrease in long-chain (LC) n-6 PUFA at 3 weeks. Elevated fibrinogen (2.6-3.9 g/l) decreased by 0.95 g/l at 6 weeks. Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at low fibrinogen levels only. The associations and changes in plasma C18 and LC PUFA followed the competitive and metabolic principles of the body, and especially in the case of n-3 PUFA according to the recycling pathway.
研究了菜籽油（RSO）对血清脂质、血浆纤维蛋白原、脂质氧化和脂肪酸的影响，该研究涉及三组受试者，其中两组在其习惯性饮食中不食用鱼类。42 名志愿者（35 名女性，7 名男性，年龄 16-62 岁）以平行设计的方式用 RSO 替代脂肪，为期 6 周。胆固醇和纤维蛋白原的平均浓度分别为 5.0mmol/L 和 2.6g/L。α-亚麻酸（α-LLA）的摄入量增加了一倍。在 3 周时，α-LLA 的有效竞争抑制作用表现为长链（LC）n-6 PUFA 的减少。在 6 周时，升高的纤维蛋白原（2.6-3.9g/L）降低了 0.95g/L。只有在低纤维蛋白原水平时，二十二碳六烯酸（22:6n-3）在血浆磷脂中增加。C18 和 LC PUFA 的变化和相关性遵循身体的竞争和代谢原则，尤其是在 n-3 PUFA 方面，遵循的是再循环途径。
