Xu Jiqu, Ma Congcong, Han Ling, Gao Hui, Zhou Qi, Yang Mei, Chen Chang, Deng Qianchun, Huang Qingde, Huang Fenghong
Department of Product Processing and Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, P,R, China.
Lipids Health Dis. 2014 Oct 30;13:166. doi: 10.1186/1476-511X-13-166.
Micronutrients in rapeseed such as polyphenols, tocopherols, phytosterols and phospholipids in rapeseed exert potential benefit to atherosclerosis. Some part of these healthy components substantially lost during the conventional refining processing. Thus some new processing technologies have been developed to produce various endogenous micronutrient-enriched optimized rapeseed oils. The aim of this study is to assess whether optimized rapeseed oils have positive effects on the atherosclerosis risk factors in rats fed a high-fat diet.
Rats received experiment diets containing 20% fat and refined rapeseed oil or optimized rapeseed oils obtained with various processing technologies as lipid source. After 10 weeks of treatment, plasma was assayed for oxidative stress, lipid profiles and imflammation.
Micronutrients enhancement in optimized rapeseed oils significantly reduced plasma oxidative stress, as evaluated by the significant elevation in the activities of CAT and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. Optimized rapeseed oil with the highest micronutrient contents obtained by microwave pretreatment-cold pressing reduced the levels of TG, TC and LDL-C as well as IL-6 and CRP in plasma.
These results suggest that optimized rapeseed oils may contribute to prevent atherogenesis and make them very promising functional food in cardiovascular health promotion.
油菜籽中的微量营养素，如多酚、生育酚、植物甾醇和磷脂，对动脉粥样硬化具有潜在益处。这些健康成分的一部分在传统精炼加工过程中大量损失。因此，人们开发了一些新的加工技术来生产各种富含内源性微量营养素的优化菜籽油。本研究的目的是评估优化菜籽油对高脂饮食喂养大鼠的动脉粥样硬化危险因素是否有积极影响。
大鼠接受含20%脂肪的实验饮食，并以精炼菜籽油或通过各种加工技术获得的优化菜籽油作为脂质来源。治疗10周后，检测血浆中的氧化应激、血脂谱和炎症指标。
通过CAT和GPx活性以及GSH水平的显著升高以及脂质过氧化的显著下降来评估，优化菜籽油中微量营养素的增加显著降低了血浆氧化应激。通过微波预处理-冷榨获得的微量营养素含量最高的优化菜籽油降低了血浆中TG、TC和LDL-C以及IL-6和CRP的水平。
这些结果表明，优化菜籽油可能有助于预防动脉粥样硬化的发生，并使其成为促进心血管健康的非常有前景的功能性食品。
