蛋白质结构的多样性与折叠识别的困难：蛋白质G的奇特案例。
Diversity of protein structures and difficulties in fold recognition: the curious case of protein G.
作者信息
Horst Jeremy, Samudrala Ram
出版信息
F1000 Biol Rep. 2009 Sep 8;1:69. doi: 10.3410/B1-69.
Abstract
We examine the ability of current state-of-the-art methods in protein structure prediction to discriminate topologically distant folds encoded by highly similar (>90% sequence identity) designed proteins in blind protein structure prediction experiments. We detail the corresponding prognosis for the protein fold recognition field and highlight the features of the methodologies that successfully deciphered this folding riddle.
摘要
我们在盲蛋白结构预测实验中，检验了当前蛋白质结构预测领域最先进方法，对由高度相似（序列同一性>90%）的设计蛋白编码的拓扑距离较远的折叠进行区分的能力。我们详细阐述了蛋白质折叠识别领域的相应预测，并突出了成功破解这一折叠谜题的方法的特点。
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