血管力学、机械生物学与重塑
VASCULAR MECHANICS, MECHANOBIOLOGY, AND REMODELING.
作者信息
Humphrey J D
机构信息
Department of Biomedical Engineering, 337 Zachry Engineering Center, Texas A&M University, College Station, TX 77843-3120 USA.
出版信息
J Mech Med Biol. 2009;9(2):243-257. doi: 10.1142/S021951940900295X.
Abstract
Arteries exhibit a remarkable ability to adapt in response to sustained alterations in hemodynamic loading as well as in response to disease, injury, and clinical treatment. A better understanding of such adaptations will be aided greatly by formulating, testing, and refining appropriate theoretical frameworks for modeling the biomechanics and associated mechanobiology. The goal of this brief review is to highlight some recent developments in the use of a constrained mixture theory of arterial growth and remodeling, with particular attention to the requisite constitutive relations, and to highlight future directions of needed research.
摘要
动脉展现出显著的能力，能够适应血流动力学负荷的持续变化，以及疾病、损伤和临床治疗所带来的影响。通过构建、测试和完善适用于动脉生物力学及相关力学生物学建模的理论框架，将极大地有助于更深入地理解这些适应性变化。本简要综述的目的是强调在动脉生长和重塑的约束混合物理论应用方面的一些最新进展，尤其关注必要的本构关系，并突出未来所需研究的方向。
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