Bitnun A, Nosal R M
Division of Infectious Diseases, The Hospital for Sick Children, Toronto;
Paediatr Child Health. 1999 Mar;4(2):125-9. doi: 10.1093/pch/4.2.125.
In 1998, widespread contamination of water-damaged school portables with the toxigenic mold Stachybotrys chartarum was detected in the province of Ontario. This mold may cause human disease through direct irritation, type 1 hypersensitivity or the production of toxins. A variety of respiratory, dermatological, eye and constitutional symptoms have been associated with heavy and prolonged exposure to S chartarum. S chartarum has also been potentially implicated as a rare cause of idiopathic pulmonary hemorrhage in infants. Ingestion of food heavily contaminated with toxin-producing molds, including S chartarum, can cause bone marrow suppression and immunotoxicity. However, the level of toxin exposure that occurs following inhalation of S chartarum is very low; consequently, serious adverse health effects from such an exposure are extremely unlikely. In a child with symptoms felt to be temporally related to the school environment, an assessment of the child's school should be carried out by the public health authorities so that potential irritants and allergens can be identified. Avoidance of exposure is the most effective mode of therapy. Buildings found to be heavily contaminated with molds, particularly S chartarum, should undergo thorough cleaning and repair to remove the offending agent(s), and prevent further water damage and mold overgrowth.
1998年,安大略省检测到受水浸损坏的学校活动板房被产毒霉菌——葡萄穗霉广泛污染。这种霉菌可通过直接刺激、Ⅰ型超敏反应或产生毒素引发人类疾病。大量长期接触葡萄穗霉会引发多种呼吸道、皮肤、眼部及全身症状。葡萄穗霉还可能是婴儿特发性肺出血的罕见病因。摄入被包括葡萄穗霉在内的产毒霉菌严重污染的食物会导致骨髓抑制和免疫毒性。然而,吸入葡萄穗霉后的毒素暴露水平非常低;因此,这种暴露引发严重不良健康影响的可能性极小。对于出现与学校环境在时间上相关症状的儿童,公共卫生当局应对其学校进行评估,以便识别潜在的刺激物和过敏原。避免接触是最有效的治疗方式。被发现被霉菌严重污染,尤其是被葡萄穗霉污染的建筑物,应进行彻底清洁和修复,以清除致病因素,并防止进一步的水浸损坏和霉菌滋生。