Boffetta Paolo, van der Hel Olga, Kricker Anne, Nieters Alexandra, de Sanjosé Silvia, Maynadié Marc, Cocco Pier Luigi, Staines Anthony, Becker Nikolaus, Font Rebecca, Mannetje Andrea 't, Goumas Chris, Brennan Paul
International Agency for Research on Cancer, Lyon, France.
Int J Epidemiol. 2008 Oct;37(5):1080-94. doi: 10.1093/ije/dyn092. Epub 2008 May 29.
Three recent studies have reported a decreased risk of non-Hodgkin lymphoma (NHL) for high ultraviolet (UV) radiation exposure.
We conducted a multicentre case-control study during 1998-2004 in France, Germany, Ireland, Italy and Spain, comprising 1518 cases of NHL, 268 cases of Hodgkin lymphoma, 242 cases of multiple myeloma and 2124 population or hospital controls. We collected information on sensitivity to sun and personal exposure to UV radiation in childhood and adulthood via interview, and assessed occupational exposure to UV radiation from the occupational history.
The risk of Hodgkin and NHL was increased for increasing skin sensitivity to the sun [odds ratio (OR) for no suntan vs very brown 2.35, 95% CI 0.94-5.87 and 1.39, 95% CI 1.03-1.87, respectively]. The risk of diffuse large B-cell lymphoma was reduced for increasing adult personal (OR for highest vs lowest quartile of exposure in free days 0.62, 95% CI 0.44-0.87) and for occupational exposure to UV radiation (OR for highest vs lowest exposure tertile 0.63, 95% CI 0.37-1.04). The risk of multiple myeloma was increased for personal exposure to UV radiation during adulthood (OR for highest vs lowest quartile of exposure in free days 1.49, 95% CI 0.88-2.50). A protective effect was observed for use of sun lamps for diffuse large B-cell lymphoma (OR for 25+ times vs never 0.63, 95% CI 0.38-1.03).
The hypothesis of a protective effect of UV radiation on lymphoma is supported by our results. The underlying mechanisms might differ from those operating in skin carcinogenesis. The increased risk of multiple myeloma is worth replication.
最近三项研究报告称，高紫外线（UV）辐射暴露可降低非霍奇金淋巴瘤（NHL）的风险。
1998年至2004年期间，我们在法国、德国、爱尔兰、意大利和西班牙开展了一项多中心病例对照研究，包括1518例NHL患者、268例霍奇金淋巴瘤患者、242例多发性骨髓瘤患者以及2124名人群或医院对照。我们通过访谈收集了儿童期和成年期对阳光的敏感性以及个人紫外线辐射暴露的信息，并根据职业史评估职业性紫外线辐射暴露情况。
皮肤对阳光的敏感性增加，霍奇金淋巴瘤和NHL的风险升高[未晒黑与肤色很深相比的比值比（OR）分别为2.35，95%可信区间（CI）0.94 - 5.87和1.39，95%CI 1.03 - 1.87]。成人个人紫外线辐射暴露增加（休息日暴露最高四分位数与最低四分位数相比的OR为0.62，95%CI 0.44 - 0.87）以及职业性紫外线辐射暴露，弥漫性大B细胞淋巴瘤的风险降低（最高暴露三分位数与最低暴露三分位数相比的OR为0.63，95%CI 0.37 - 1.04）。成年期个人紫外线辐射暴露，多发性骨髓瘤的风险增加（休息日暴露最高四分位数与最低四分位数相比的OR为1.49，95%CI 0.88 - 2.50）。对于弥漫性大B细胞淋巴瘤，观察到使用太阳灯有保护作用（使用25次以上与从未使用相比的OR为0.63，95%CI 0.38 - 1.03）。
我们的结果支持紫外线辐射对淋巴瘤有保护作用的假说。其潜在机制可能与皮肤癌发生的机制不同。多发性骨髓瘤风险增加这一结果值得重复验证。
