Craig E W, Griffiths P G
Department of Ophthalmology, Newcastle General Hospital, Newcastle upon Tyne.
Br J Ophthalmol. 1991 Apr;75(4):222-3. doi: 10.1136/bjo.75.4.222.
The cardiovascular effects of topically administered phenylephrine 10% are well known and can be minimised by reducing the concentration of drops administered. By modifying the dimensions of the dropper tip we reduced the volume of the drops administered, and therefore the total dose of phenylephrine, without altering the concentration. No difference in the mydriasis produced by drops of small and normal volume could be detected. Since a smaller dose of phenylephrine is administered with smaller drops, the risk of systemic side effects could be reduced by modifying the tips of eyedroppers.
局部应用10%去氧肾上腺素的心血管效应是众所周知的，通过降低给药滴眼液的浓度可将其影响降至最低。通过改变滴管尖端的尺寸，我们减少了给药的液滴体积，从而减少了去氧肾上腺素的总剂量，而不改变其浓度。未检测到小体积和正常体积液滴产生的瞳孔散大存在差异。由于使用较小液滴时去氧肾上腺素的给药剂量较小，因此通过改变滴管尖端可降低全身副作用的风险。
