Institute for Medical Virology, University Hospital Frankfurt, Paul Ehrlich Str 40, 69596, Frankfurt, Germany.
Med Microbiol Immunol. 2010 May;199(2):123-8. doi: 10.1007/s00430-010-0145-2. Epub 2010 Mar 9.
A transmission cluster of HIV-1 M:B was identified in 11 patients with a median age of 52 (range 26-65) in North-East Germany by C2V4 region sequencing of the env gene of HIV-1, who-except of one-were not aware of any risky behaviour. The 10 male and 1 female patients deteriorated immunologically, according to their information made available, within 4 years after a putative HIV acquisition. Nucleic acid sequence analysis showed a R5 virus in all patients and in 7 of 11 a crown motif of the V3 loop, GPGSALFTT, which is found rarely. Analysis of formation of this cluster showed that there is still a huge discrepancy between awareness and behaviour regarding HIV transmission in middle-aged patients, and that a local outbreak can be detected by nucleic acid analysis of the hypervariable env region.
在德国东北部，通过对 HIV-1 的 env 基因的 C2V4 区域进行测序，发现了一组 HIV-1 M:B 的传播集群，涉及 11 名中位年龄为 52 岁（26-65 岁）的患者，除了一名患者外，其他患者都不知道任何危险行为。根据可获得的信息，这 10 名男性和 1 名女性患者在疑似 HIV 感染后 4 年内免疫功能恶化。核酸序列分析显示，所有患者均为 R5 病毒，11 名患者中有 7 名 V3 环的冠形基序为 GPGSALFTT，这很少见。对该集群形成的分析表明，中年患者在 HIV 传播方面的意识和行为之间仍存在巨大差异，并且通过对高变区 env 区域的核酸分析可以检测到局部暴发。
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