MADS 结构域转录因子的起源。

On the origin of MADS-domain transcription factors.

机构信息

Department of Genetics, Friedrich Schiller University Jena, D-07743 Jena, Germany.

出版信息

Trends Genet. 2010 Apr;26(4):149-53. doi: 10.1016/j.tig.2010.01.004. Epub 2010 Mar 10.

DOI:10.1016/j.tig.2010.01.004

PMID:20219261

Abstract

MADS-domain transcription factors are involved in signal transduction and developmental control in plants, animals and fungi. Because their diversification is linked to the origin of novelties in multicellular eukaryotes, the early evolution of MADS-domain proteins is of interest, but has remained enigmatic. Employing whole genome sequence information and remote homology detection methods, we demonstrate that the MADS domain originated from a region of topoisomerases IIA subunit A. Furthermore, we provide evidence that gene duplication occurred in the lineage that led to the MRCA of extant eukaryotes, giving rise to SRF-like and MEF2-like MADS-box genes.

摘要

MADS 结构域转录因子参与植物、动物和真菌中的信号转导和发育调控。由于它们的多样化与多细胞真核生物中新奇事物的起源有关，因此 MADS 结构域蛋白的早期进化很有趣，但一直是个谜。利用全基因组序列信息和远程同源检测方法，我们证明了 MADS 结构域起源于拓扑异构酶 IIA 亚基 A 的一个区域。此外，我们还提供了证据表明，在导致现存真核生物的共同祖先的谱系中发生了基因复制，从而产生了 SRF 样和 MEF2 样的 MADS 盒基因。