State Key Laboratory of Natural and Biomimetic Drugs, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, PR China.
Neurosci Lett. 2010 Apr 26;474(2):99-103. doi: 10.1016/j.neulet.2010.03.016. Epub 2010 Mar 19.
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra (SN) with the presence of alpha-synuclein inclusions termed Lewy bodies. The neuroprotective effects of protocatechuic acid (PAc) both in vitro and in vivo have been reported. However, little is known about the effects of PAc on neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in vivo. In this study, we demonstrated that PAc inhibited the reduction of the latent periods in a rotarod test, and the contents of dopamine (DA) and its metabolites in striatum, and furthermore, it ameliorated the pathology in SN and the decreases in the expression of tyrosine hydroxylase (TH) in SN of C57BL/6J mice induced by MPTP. Taken together, our results indicate for the first time that PAc has neuroprotective effects on MPTP treated C57BL/6J mice and may be useful in clinical treatment of PD.
帕金森病（PD）的特征是黑质（SN）中多巴胺能神经元的进行性退化，存在称为路易体的α-突触核蛋白包涵体。已报道原儿茶酸（PAc）在体外和体内均具有神经保护作用。然而，对于 PAc 对体内 1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的神经毒性的影响知之甚少。在这项研究中，我们证明 PAc 抑制了旋转棒试验中潜伏期的降低，以及纹状体中多巴胺（DA）及其代谢物的含量，此外，它改善了 SN 中的病理学和 C57BL/6J 小鼠 SN 中酪氨酸羟化酶（TH）表达的降低由 MPTP 引起的。总之，我们的结果首次表明 PAc 对 MPTP 处理的 C57BL/6J 小鼠具有神经保护作用，可能对 PD 的临床治疗有用。
