水杨酸盐耳毒性：综述与综合分析

Salicylate ototoxicity: review and synthesis.

作者信息

Boettcher F A, Salvi R J

机构信息

Department of Communicative Disorders and Sciences, State University of New York, Buffalo 14214.

出版信息

Am J Otolaryngol. 1991 Jan-Feb;12(1):33-47. doi: 10.1016/0196-0709(91)90071-m.

DOI:10.1016/0196-0709(91)90071-m

PMID:2029065

Abstract

The effects of salicylates on the auditory system are reviewed. The clinical manifestations of aspirin ototoxicity are described, including changes in the sensitivity and suprathreshold characteristics of hearing, as well as tinnitus. The results of animal experiments on salicylate ototoxicity are discussed, including behavioral, anatomic, and physiologic studies examining the mechanisms of salicylate ototoxicity. The sue of salicylates in the study of the basic mechanisms of hearing and hearing loss is also considered.

摘要

本文综述了水杨酸盐对听觉系统的影响。描述了阿司匹林耳毒性的临床表现，包括听力敏感度和阈上特性的变化以及耳鸣。讨论了水杨酸盐耳毒性的动物实验结果，包括研究水杨酸盐耳毒性机制的行为学、解剖学和生理学研究。还考虑了水杨酸盐在听力和听力损失基本机制研究中的应用。