Bartmann P, Grosch-Wörner I, Wahn V, Belohradsky B H
Children's Hospital, Department II, University of Ulm, Federal Republic of Germany.
Eur J Pediatr. 1991 Feb;150(4):234-7. doi: 10.1007/BF01955519.
Infection with the human immunodeficiency virus (HIV) induces a polyclonal B-cell activation. Despite elevated serum immunoglobulin levels, a significant deterioration of the antigen specific humoral immune response exists in most cases. We studied the influence of HIV infection on the serum levels of IgG subclasses in children. We investigated 76 children (aged 15 months to 18 years) with HIV-1-infection. Most children (88%) showed elevated serum immunoglobulin levels. IgA (87%) and IgM (74%) were more often above normal levels for age than IgG (60%). IgG subclass serum levels were significantly altered. The increase in total IgG was mainly due to a marked augmentation of the IgG1 fraction. In most cases IgG3 was simultaneously elevated. Ten children (13%) had very low IgG4 levels (less than 0.03 g/l). Out of 61 patients older than 2 years 8 (13%) had a profound IgG2 deficiency with normal or elevated total IgG. Four of them also had low IgG4 levels (less than 0.03 g/l). A correlation between IgG2 deficiency and HIV infection according to the Centres for Disease Control classification for acquired immunodeficiency syndrome could not be demonstrated (three patients with symptomatic and five with asymptomatic infection).
人类免疫缺陷病毒（HIV）感染可诱导多克隆B细胞活化。尽管血清免疫球蛋白水平升高，但在大多数情况下，抗原特异性体液免疫反应会显著恶化。我们研究了HIV感染对儿童血清IgG亚类水平的影响。我们调查了76名感染HIV-1的儿童（年龄在15个月至18岁之间）。大多数儿童（88%）血清免疫球蛋白水平升高。与IgG（60%）相比，IgA（87%）和IgM（74%）高于年龄正常水平的情况更为常见。IgG亚类血清水平发生了显著变化。总IgG的增加主要是由于IgG1组分的显著增加。在大多数情况下，IgG3同时升高。10名儿童（13%）的IgG4水平非常低（低于0.03g/l）。在61名2岁以上的患者中，8名（13%）存在严重的IgG2缺乏，而总IgG正常或升高。其中4名患者的IgG4水平也很低（低于0.03g/l）。根据疾病控制中心对获得性免疫缺陷综合征的分类，无法证明IgG2缺乏与HIV感染之间存在相关性（3名有症状感染患者和5名无症状感染患者）。
