Olveira Gabriel, Olveira Casilda, Gaspar Inmaculada, Cruz Ivette, Dorado Antonio, Pérez-Ruiz Estela, Porras Nuria, Soriguer Federico
Unidad de Fibrosis Quística, Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, Málaga, Spain.
Arch Bronconeumol. 2010 Apr;46(4):165-75. doi: 10.1016/j.arbres.2010.01.006. Epub 2010 Mar 20.
The aim of this study was to assess the validity and reliability of the Spanish version of the revised disease-specific health related quality of life questionnaire for adolescents and adults with cystic fibrosis (CFQR 14+ Spain).
A total of 43 cystic fibrosis (CF) patients completed the CFQR 14+ Spain. Forced expiratory volume in 1 second, in percentage of predicted - FEV(1) (%)-, number of respiratory exacerbations, 6-minute walk test, Bhalla score (based on computerized tomography of the chest), fat-free mass index, body mass index (BMI), faecal fat and St George's Respiratory Questionnaire were included as measurements of health status.
Ten out of the twelve scales had alpha coefficients above 0.70. Test-retest correlations (Spearman) ranged from 0.49 to 0.95 and they were significant in all scales. Intraclass correlations ranged from 0.47 to 0.95 (ten out of the twelve scales were >0.70) forty out of the fifty ítems have correlations between items and scale above 0.70. All the CFQR+14 scales, except the digestive symptoms scale, discriminated significantly between patients with mild, moderate and severe disease (according to FEV(1) (%)). Other respiratory parameters also discriminated significantly between patients with mild-moderate and severe disease. Only some scales discriminated significantly between nourished and malnourished patients. All of the scales met standards for floor effects (<15% of the responders with the lowest score) but not for ceiling effects (only five out of the twelve).
The Spanish CFQR14+ (Spain) is a reliable and valid instrument for measuring the health-related quality of life in Spanish adolescents and adults with CF, though with the exception of a few of its subscales.
本研究旨在评估西班牙文版修订的针对青少年和成年囊性纤维化患者的特定疾病健康相关生活质量问卷（CFQR 14+西班牙版）的有效性和可靠性。
共有43名囊性纤维化（CF）患者完成了CFQR 14+西班牙版问卷。测量的健康状况指标包括：一秒用力呼气容积占预计值的百分比 -FEV(1)(%)-、呼吸道加重发作次数、6分钟步行试验、巴哈拉评分（基于胸部计算机断层扫描）、去脂体重指数、体重指数（BMI）、粪便脂肪以及圣乔治呼吸问卷。
十二个量表中有十个的阿尔法系数高于0.70。重测相关性（斯皮尔曼相关性）范围为0.49至0.95，且在所有量表中均具有显著性。组内相关性范围为0.47至0.95（十二个量表中有十个>0.70），五十个条目中有四十个条目的条目与量表之间的相关性高于0.70。除消化症状量表外，所有CFQR +14量表在轻度、中度和重度疾病患者（根据FEV(1)(%)）之间均有显著差异。其他呼吸参数在轻度-中度和重度疾病患者之间也有显著差异。只有一些量表在营养良好和营养不良患者之间有显著差异。所有量表均符合地板效应标准（得分最低的应答者中<15%），但不符合天花板效应标准（十二个量表中只有五个符合）。
西班牙文CFQR14+（西班牙版）是一种可靠且有效的工具，可用于测量西班牙青少年和成年CF患者的健康相关生活质量，不过其少数子量表除外。
