Pneumology Service, Hospital Regional Universitario de Málaga. IBIMA (Instituto de Investigación Biomédica de Málaga), Universidad de Málaga, Avenida Carlos Haya, 29010, Malaga, Spain,
Qual Life Res. 2014 May;23(4):1279-92. doi: 10.1007/s11136-013-0560-0. Epub 2013 Oct 19.
Bronchiectasis is a chronic disease, leading to worsening of health-related quality of life. This study evaluated the psychometric properties of a new patient-reported outcome for non-cystic fibrosis bronchiectasis, the Quality of Life Questionnaire Bronchiectasis, translated into Spanish (QOL-B-Sp-V3.0).
This prospective study recruited clinically stable patients with non-cystic fibrosis bronchiectasis at 4 Spanish centers. Health status was assessed with multiple indicators (dyspnea, exacerbations, bronchorrhea, etc.), microbiological, radiological, spirometric, and anthropometric parameters plus St-George Respiratory Questionnaire (SGRQ). Psychometric analyses included internal consistency, test-retest reliability, convergent validity, predictive validity, and responsivity to change.
The 207 stable patients (mean age 57.2 years) had a Bhalla score of 11.53 ± 7.39 and FEV1% of 68.3 ± 22.2 %. One hundred and sixty-one stable patients repeated the test 2 weeks later, and 80 patients who had an exacerbation within 6 months of the assessment also repeated it. Internal consistency was high across all scales (Cronbach's alpha >0.70). Thirty-six of 37 items correlated more strongly with their assigned scale than a competing scale. Test-retest coefficients were strong (intraclass correlations r = 0.68-0.88). All scales, except Treatment Burden, discriminated significantly between patients with mild, moderate, and severe disease according to FEV1% and other respiratory parameters. Strong convergence was found between the QOL-B-Sp-V3.0 and SGRQ. Significant correlations were found between QOL-B-Sp-V3.0 and various clinical, spirometric, radiological, and anthropometric variables. Significant differences were found on all QOL-B-Sp-V3.0 scales, except emotional functioning, between the baseline responses and onset of an exacerbation; robust sensitivity to change was observed on the Respiratory Symptoms scale.
The QOL-B-Sp-V3.0 questionnaire demonstrated strong reliability and validity. Scores were reproducible after 2 weeks, and it discriminated between patients who varied in severity and was responsive to changes related to exacerbation.
支气管扩张症是一种慢性病，导致健康相关生活质量下降。本研究评估了一种新的非囊性纤维化支气管扩张症患者报告结局的心理计量学特性，即支气管扩张症生活质量问卷，该问卷已被翻译成西班牙语（QOL-B-Sp-V3.0）。
这项前瞻性研究在西班牙的 4 个中心招募了临床稳定的非囊性纤维化支气管扩张症患者。健康状况通过多种指标（呼吸困难、恶化、支气管分泌物等）、微生物学、影像学、肺量计和人体测量参数以及圣乔治呼吸问卷（SGRQ）进行评估。心理计量学分析包括内部一致性、重测信度、收敛有效性、预测有效性和对变化的反应性。
207 名稳定患者（平均年龄 57.2 岁）的 Bhalla 评分（11.53 ± 7.39）和 FEV1%（68.3 ± 22.2%）。161 名稳定患者在 2 周后重复了该测试，80 名在评估后 6 个月内发生恶化的患者也重复了该测试。所有量表的内部一致性均较高（Cronbach's alpha >0.70）。37 个项目中的 36 个与各自的量表相关性更强，而不是与竞争量表的相关性更强。测试-重测系数较强（组内相关系数 r = 0.68-0.88）。除治疗负担外，所有量表均根据 FEV1%和其他呼吸参数显著区分了轻度、中度和重度疾病的患者。QOL-B-Sp-V3.0 与 SGRQ 之间存在很强的收敛性。在 QOL-B-Sp-V3.0 与各种临床、肺量计、影像学和人体测量变量之间发现了显著的相关性。在基线反应和恶化发作之间，除了情绪功能外，在 QOL-B-Sp-V3.0 的所有量表上都发现了显著差异；在呼吸症状量表上观察到了对变化的强烈敏感性。
QOL-B-Sp-V3.0 问卷表现出很强的可靠性和有效性。两周后评分可重复，可区分严重程度不同的患者，并对与恶化相关的变化做出反应。
