来自中国南海软珊瑚美丽肉芝软珊瑚的生物活性柳珊瑚类化合物。
Bioactive cembranoids from the South China Sea soft coral Sarcophyton elegans.
作者信息
Liu Xin, Zhang Junsheng, Liu Qiao, Tang Guihua, Wang Hongsheng, Fan Chengqi, Yin Sheng
机构信息
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China.
出版信息
Molecules. 2015 Jul 22;20(7):13324-35. doi: 10.3390/molecules200713324.
Four new cembranoids, sarcophelegans A-D (1-4) and six known analogues (5-10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction. The antimigratory potential of compounds 1-10 were evaluated and compounds 2 and 6 were found to inhibit human breast tumor MDA-MB-231 cell migration at 10 μM.
从中国南海软珊瑚美丽肉芝软珊瑚中分离出4个新的西松烷型二萜，即肉芝软珊瑚素A-D（1-4）和6个已知类似物（5-10）。通过详细的光谱分析阐明了它们的结构，1的绝对构型通过单晶X射线衍射得到确证。对化合物1-10的抗迁移潜力进行了评估，发现化合物2和6在10 μM时可抑制人乳腺肿瘤MDA-MB-231细胞的迁移。
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