癌症患者的长期生存与心力衰竭和中风的比较：系统综述。
Long-term survival of cancer patients compared to heart failure and stroke: a systematic review.
机构信息
Department of Radiooncology and Radiation Therapy, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
出版信息
BMC Cancer. 2010 Mar 22;10:105. doi: 10.1186/1471-2407-10-105.
BACKGROUND
Cancer, heart failure and stroke are among the most common causes of death worldwide. Investigation of the prognostic impact of each disease is important, especially for a better understanding of competing risks. Aim of this study is to provide an overview of long term survival of cancer, heart failure and stroke patients based on the results of large population- and hospital-based studies.
METHODS
Records for our study were identified by searches of Medline via Pubmed. We focused on observed and relative age- and sex-adjusted 5-year survival rates for cancer in general and for the four most common malignancies in developed countries, i.e. lung, breast, prostate and colorectal cancer, as well as for heart failure and stroke.
RESULTS
Twenty studies were identified and included for analysis. Five-year observed survival was about 43% for all cancer entities, 40-68% for stroke and 26-52% for heart failure. Five-year age and sex adjusted relative survival was 50-57% for all cancer entities, about 50% for stroke and about 62% for heart failure. In regard to the four most common malignancies in developed countries 5-year relative survival was 12-18% for lung cancer, 73-89% for breast cancer, 50-99% for prostate cancer and about 43-63% for colorectal cancer. Trend analysis revealed a survival improvement over the last decades.
CONCLUSIONS
The results indicate that long term survival and prognosis of cancer is not necessarily worse than that of heart failure and stroke. However, a comparison of the prognostic impact of the different diseases is limited, corroborating the necessity for further systematic investigation of competing risks.
背景
癌症、心力衰竭和中风是全球最常见的死亡原因之一。研究每种疾病的预后影响很重要，尤其是为了更好地了解竞争风险。本研究的目的是根据大型人群和医院基础研究的结果，提供癌症、心力衰竭和中风患者长期生存的概述。
方法
通过 Medline 在 Pubmed 上进行检索，确定了我们研究的记录。我们专注于观察和相对年龄及性别调整的 5 年生存率，包括一般癌症以及发达国家四种最常见的恶性肿瘤，即肺癌、乳腺癌、前列腺癌和结直肠癌，以及心力衰竭和中风。
结果
确定了 20 项研究并纳入分析。所有癌症实体的 5 年观察生存率约为 43%，中风为 40-68%，心力衰竭为 26-52%。所有癌症实体的 5 年年龄和性别调整相对生存率为 50-57%，中风约为 50%，心力衰竭约为 62%。在发达国家四种最常见的恶性肿瘤中，肺癌的 5 年相对生存率为 12-18%，乳腺癌为 73-89%，前列腺癌为 50-99%，结直肠癌为 43-63%。趋势分析显示，过去几十年生存率有所提高。
结论
结果表明，癌症的长期生存和预后不一定比心力衰竭和中风差。然而，不同疾病预后影响的比较受到限制，这证实了进一步系统研究竞争风险的必要性。
Zotero 插件