接受人工表面活性剂（ALEC）治疗的早产儿的呼吸顺应性。
Respiratory compliance in premature babies treated with artificial surfactant (ALEC).
作者信息
Morley C J, Greenough A
机构信息
Department of Paediatrics, University of Cambridge.
出版信息
Arch Dis Child. 1991 Apr;66(4):467-71. doi: 10.1136/adc.66.4.467.
Abstract
In a randomised trial of artificial surfactant (ALEC) given at birth to 294 babies less than 34 weeks' gestation, the respiratory compliance was measured at 1, 6, 24, 48, and 168 hours after birth. In babies less than 29 weeks' gestation ALEC significantly improved the mean (SEM) compliance at 6 hours from 0.54 (0.06) to 0.91 (0.13) ml/cm H2O/kg and at 24 hours from 0.57 (0.04) to 0.92 (0.10) ml/cm H2O/kg. The improvements at 1, 48, and 168 hours were not significant. In babies of over 29 weeks' gestation the compliance was lower in the ALEC treated babies. This was significant only at one hour: 0.52 (0.03) compared with 0.71 (0.07) ml/cm H2O/kg and only occurred in babies who were not ventilated.
摘要
在一项针对294名孕周小于34周的婴儿出生时给予人工表面活性物质（ALEC）的随机试验中，在出生后1、6、24、48和168小时测量呼吸顺应性。在孕周小于29周的婴儿中，ALEC显著改善了6小时时的平均（标准误）顺应性，从0.54（0.06）ml/cm H₂O/kg提高到0.91（0.13）ml/cm H₂O/kg，24小时时从0.57（0.04）ml/cm H₂O/kg提高到0.92（0.10）ml/cm H₂O/kg。在1、48和168小时时的改善不显著。在孕周超过29周的婴儿中，接受ALEC治疗的婴儿顺应性较低。这仅在1小时时显著：分别为0.52（0.03）与0.71（0.07）ml/cm H₂O/kg，且仅发生在未通气的婴儿中。
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