新型抗生素，呋喃喹诺菌素C、D、E、F、G和H。

Novel antibiotics, furaquinocins C, D, E, F, G and H.

作者信息

Ishibashi M, Funayama S, Anraku Y, Komiyama K, Omura S

机构信息

Kitasato Institute, Kitasato University, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1991 Apr;44(4):390-5. doi: 10.7164/antibiotics.44.390.

DOI:10.7164/antibiotics.44.390

PMID:2032947

Abstract

Furaquinocins C, D, E, F, G and H, congeners of furaquinocins A and B, were isolated from the culture broth of Streptomyces sp. KO-3988 and their structures have been determined on the basis of their spectroscopical and chemical properties. These antibiotics showed cytocidal activities against HeLa S3 and B16 melanoma cells in vitro.

摘要

呋喃喹诺菌素C、D、E、F、G和H是呋喃喹诺菌素A和B的同系物，从链霉菌属KO - 3988的培养液中分离得到，其结构已根据光谱和化学性质确定。这些抗生素在体外对HeLa S3和B16黑色素瘤细胞显示出杀细胞活性。