Department of Chemistry, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Anal Chem. 2010 Apr 15;82(8):3124-31. doi: 10.1021/ac100345v.
Here we demonstrate the use of microstereolithography (MSL), a 3D direct manufacturing technique, as a viable method to produce small-scale microfluidic components for electrochemical flow detection. The flow cell is assembled simply by resting the microfabricated component on the electrode of interest and securing with thread! This configuration allows the use of a wide range of electrode materials. Furthermore, our approach eliminates the need for additional sealing methods, such as adhesives, waxes, and screws, which have previously been deployed. In addition, it removes any issues associated with compression of the cell chamber. MSL allows a reduction of the dimensions of the channel geometry (and the resultant component) and, compared to most previously produced devices, it offers a high degree of flexibility in the design, reduced manufacture time, and high reliability. Importantly, the polymer utilized does not distort so that the cell maintains well-defined geometrical dimensions after assembly. For the studies herein the channel dimensions were 3 mm wide, 3.5 mm long, and 192 or 250 mum high. The channel flow cell dimensions were chosen to ensure that the substrate electrodes experienced laminar flow conditions, even with volume flow rates of up to 64 mL min(-1) (the limit of our pumping system). The steady-state transport-limited current response, for the oxidation of ferrocenylmethyl trimethylammonium hexaflorophosphate (FcTMA(+)), at gold and polycrystalline boron doped diamond (pBDD) band electrodes was in agreement with the Levich equation and/or finite element simulations of mass transport. We believe that this method of creating and using channel flow electrodes offers a wide range of new applications from electroanalysis to electrocatalysis.
在这里，我们展示了微立体光刻（MSL）的应用，这是一种 3D 直接制造技术，可作为用于电化学流动检测的小规模微流控组件的可行制造方法。流动池通过将微加工组件简单地放置在感兴趣的电极上并用螺纹固定来组装！这种配置允许使用广泛的电极材料。此外，我们的方法消除了对额外密封方法的需求，例如以前使用的粘合剂、蜡和螺丝。此外，它消除了与池室压缩相关的任何问题。MSL 允许减小通道几何形状的尺寸（和由此产生的组件），并且与大多数以前生产的设备相比，它在设计上具有高度的灵活性、制造时间的缩短和可靠性高。重要的是，所使用的聚合物不会变形，因此在组装后电池保持良好定义的几何尺寸。在本文的研究中，通道尺寸为 3 毫米宽、3.5 毫米长和 192 或 250 微米高。通道流动池尺寸的选择确保了基底电极经历层流条件，即使体积流速高达 64 mL min(-1)（我们的泵送系统的极限）。金和多晶硼掺杂金刚石（pBDD）带电极上氧化二茂铁基三甲基铵六氟磷酸盐（FcTMA(+)）的稳态传质限制电流响应与莱维奇方程和/或质量传输的有限元模拟一致。我们相信，这种创建和使用通道流动电极的方法为从电分析到电催化的广泛新应用提供了可能性。
