Northcutt A D, Nelson D M, Tschen J A
Department of Pathology (Dermatopathology Section), Baylor College of Medicine, Houston, TX.
J Am Acad Dermatol. 1991 Apr;24(4):541-4. doi: 10.1016/0190-9622(91)70078-g.
The term axillary granular parakeratosis is proposed for a unique axillary eruption with distinct histopathologic features. Four middle-aged to elderly patients (three women, one man) had unilateral or bilateral, usually pruritic, hyperpigmented to bright red patches in the axillae. Biopsy specimens revealed severe compact parakeratosis with the stratum corneum measuring 80 to 250 microns in maximal thickness, maintenance of the stratum granulosum, remarkable retention of keratohyaline granules throughout the stratum corneum, and vascular proliferation and ectasia. A contact reaction to an antiperspirant/deodorant is suspected as the cause. We speculate that the offending agent alters the maturation sequence of the stratum granulosum and stratum corneum, possibly by interfering with the degradation of filaggrin precursor to filaggrin units.
提出“腋窝颗粒状角化不全”这一术语，用于描述一种具有独特组织病理学特征的腋窝皮疹。4例中年至老年患者（3例女性，1例男性）腋窝出现单侧或双侧、通常瘙痒的、色素沉着至鲜红色斑片。活检标本显示严重的致密角化不全，角质层最大厚度为80至250微米，颗粒层保留，角质透明颗粒在整个角质层中显著留存，以及血管增生和扩张。怀疑病因是对抗汗剂/除臭剂的接触反应。我们推测，致病因子可能通过干扰丝聚蛋白前体降解为丝聚蛋白单位，改变颗粒层和角质层的成熟顺序。
