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富含γ-谷维素的馏分调节应激大鼠肝脏中抗氧化和氧化应激相关基因的表达。

Gamma-oryzanol rich fraction regulates the expression of antioxidant and oxidative stress related genes in stressed rat's liver.

机构信息

Nutrigenomics Programme, Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia.

出版信息

Nutr Metab (Lond). 2010 Mar 24;7:23. doi: 10.1186/1743-7075-7-23.

DOI:10.1186/1743-7075-7-23
PMID:20331906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2859356/
Abstract

BACKGROUND

Gamma-oryzanol (OR), a phytosteryl ferulate mixture extracted from rice bran oil, has a wide spectrum of biological activities in particular, it has antioxidant properties.

METHODS

The regulatory effect of gamma-oryzanol rich fraction (ORF) extracted and fractionated from rice bran using supercritical fluid extraction (SFE) in comparison with commercially available OR on 14 antioxidant and oxidative stress related genes was determined in rat liver. Rats were subjected to a swimming exercise program for 10 weeks to induce stress and were further treated with either ORF at 125, 250 and 500 mg/kg or OR at 100 mg/kg in emulsion forms for the last 5 weeks of the swimming program being carried out. The GenomeLab Genetic Analysis System (GeXPS) was used to study the multiplex gene expression of the selected genes.

RESULTS

Upon comparison of RNA expression levels between the stressed and untreated group (PC) and the unstressed and untreated group (NC), seven genes were found to be down-regulated, while seven genes were up-regulated in PC group compared to NC group. Further treatment of stressed rats with ORF at different doses and OR resulted in up-regulation of 10 genes and down regulation of four genes compared to the PC group.

CONCLUSIONS

Gamma-oryzanol rich fraction showed potential antioxidant activity greater than OR in the regulation of antioxidants and oxidative stress gene markers.

摘要

背景

γ-谷维素（OR）是从米糠油中提取的植物甾醇阿魏酸酯混合物，具有广泛的生物活性，特别是具有抗氧化特性。

方法

使用超临界流体萃取（SFE）从米糠中提取和分级的γ-谷维素丰富部分（ORF），与市售 OR 相比，在大鼠肝脏中对 14 种抗氧化和氧化应激相关基因的调节作用进行了测定。大鼠进行了 10 周的游泳运动计划以诱导应激，然后在游泳计划的最后 5 周内，以乳液形式用 ORF 以 125、250 和 500mg/kg 或 OR 以 100mg/kg 进行处理。使用 GenomeLab 遗传分析系统（GeXPS）研究了所选基因的多重基因表达。

结果

将应激和未处理组（PC）与非应激和未处理组（NC）之间的 RNA 表达水平进行比较，发现有 7 个基因下调，而 PC 组中 7 个基因上调与 NC 组相比。与 PC 组相比，用不同剂量的 ORF 和 OR 进一步处理应激大鼠，导致 10 个基因上调和 4 个基因下调。

结论

γ-谷维素丰富部分在调节抗氧化剂和氧化应激基因标志物方面表现出比 OR 更强的抗氧化活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/e9374a4abdae/1743-7075-7-23-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/532ceb81aa0a/1743-7075-7-23-1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/381497d5b795/1743-7075-7-23-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/7b07a4da655d/1743-7075-7-23-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/a7aa0467a843/1743-7075-7-23-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/68493dc12bf2/1743-7075-7-23-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/37012191f0a0/1743-7075-7-23-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/e9374a4abdae/1743-7075-7-23-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/532ceb81aa0a/1743-7075-7-23-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/7cad35d31b87/1743-7075-7-23-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/761e129533c4/1743-7075-7-23-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/381497d5b795/1743-7075-7-23-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/7b07a4da655d/1743-7075-7-23-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/a7aa0467a843/1743-7075-7-23-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/68493dc12bf2/1743-7075-7-23-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/37012191f0a0/1743-7075-7-23-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a931/2859356/e9374a4abdae/1743-7075-7-23-9.jpg

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