Burstein M, Monge E, León-Barúa R, Lozano R, Berendson R, Gilman R H, Legua H, Rodriguez C
Program for Early Detection of Gastric Cancer, Daniel A. Carrión Hospital, Callao, Peru.
J Clin Gastroenterol. 1991 Apr;13(2):154-6. doi: 10.1097/00004836-199104000-00007.
We compared the prevalence rates of peptic ulcer (duodenal and gastric) and gastric cancer in 1,796 dyspeptic Peruvian patients with those reported in 2,883 similar patients from developed countries. The prevalence of total peptic ulcer was significantly lower, and that of gastric cancer significantly higher, in the Peruvian patients. The prevalence of gastric ulcer was lower but not significantly so. We deduced that the significantly lower prevalence of total peptic ulcer was directly related to the low prevalence rate of duodenal ulcer. We hypothesize that the reason for these differences was probably a higher prevalence of Helicobacter pylori-associated chronic atrophic gastritis with hypochlorhydria in the Peruvian patients. Hypochlorhydria decreases the predisposition to peptic ulcer (especially duodenal ulcer), and chronic atrophic gastritis may predispose an individual to gastric cancer.
我们比较了1796名患有消化不良的秘鲁患者的消化性溃疡（十二指肠溃疡和胃溃疡）及胃癌患病率与2883名来自发达国家的类似患者的相关患病率。秘鲁患者中消化性溃疡的总患病率显著较低，而胃癌的患病率则显著较高。胃溃疡的患病率较低，但差异不显著。我们推断，消化性溃疡总患病率显著较低与十二指肠溃疡患病率低直接相关。我们推测，这些差异的原因可能是秘鲁患者中幽门螺杆菌相关性慢性萎缩性胃炎伴胃酸过少的患病率较高。胃酸过少会降低患消化性溃疡（尤其是十二指肠溃疡）的易感性，而慢性萎缩性胃炎可能使个体易患胃癌。
