运动科学研究：我们现在在哪里，以及我们从哪里出发——第二部分。
Research in the exercise sciences: where we are and where do we go from here--Part II.
机构信息
Department of Physiology and Biophysics, University of California-Irvine, Irvine, CA 92697, USA.
出版信息
Exerc Sport Sci Rev. 2010 Apr;38(2):42-50. doi: 10.1097/JES.0b013e3181d49644.
Abstract
This decadal perspective summarizes novel, insightful observations achieved in exercise science. The topics span genomics and gene function, epigenetics, cell signaling, epidemiological phenomena, and other important areas. A future strategy is presented along two parallel, integrated paths involving the following: 1) a continuance of genomic discovery and gene function, and 2) classical biochemical/physiological approaches toward solving biological- and health/disease-related phenomena.
摘要
这篇十年展望总结了在运动科学领域取得的新颖而有见地的观察结果。这些主题涵盖了基因组学和基因功能、表观遗传学、细胞信号转导、流行病学现象以及其他重要领域。本文提出了未来的策略，涉及两个平行的整合路径：1）继续进行基因组发现和基因功能研究，2）采用经典的生化/生理学方法解决与生物学和健康/疾病相关的现象。
相似文献
1
Research in the exercise sciences: where we are and where do we go from here--Part II.运动科学研究：我们现在在哪里，以及我们从哪里出发——第二部分。
Exerc Sport Sci Rev. 2010 Apr;38(2):42-50. doi: 10.1097/JES.0b013e3181d49644.
2
The Interplay Between Exercise Metabolism, Epigenetics, and Skeletal Muscle Remodeling.运动代谢、表观遗传学与骨骼肌重塑的相互作用。
Exerc Sport Sci Rev. 2020 Oct;48(4):188-200. doi: 10.1249/JES.0000000000000227.
3
Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling.随着年龄增长，骨骼肌微小RNA表达减少与肌肉可塑性减弱及胰岛素样生长因子-1（IGF-1）信号传导受抑制有关。
FASEB J. 2014 Sep;28(9):4133-47. doi: 10.1096/fj.14-254490. Epub 2014 Jun 13.
4
The effect of exercise and physical activity on skeletal muscle epigenetics and metabolic adaptations.运动和身体活动对骨骼肌表观遗传学及代谢适应性的影响。
Eur J Appl Physiol. 2025 Mar;125(3):611-627. doi: 10.1007/s00421-025-05704-6. Epub 2025 Jan 8.
5
Exercise and the Skeletal Muscle Epigenome.运动与骨骼肌表观基因组。
Cold Spring Harb Perspect Med. 2017 Sep 1;7(9):a029876. doi: 10.1101/cshperspect.a029876.
6
Research in the exercise sciences: where do we go from here?
J Appl Physiol (1985). 2000 Jan;88(1):332-6. doi: 10.1152/jappl.2000.88.1.332.
7
Exercise and the nitric oxide vasodilator system.运动与一氧化氮血管舒张系统
Sports Med. 2003;33(14):1013-35. doi: 10.2165/00007256-200333140-00001.
8
Epigenetics and Exercise.表观遗传学与运动。
Trends Endocrinol Metab. 2019 Sep;30(9):636-645. doi: 10.1016/j.tem.2019.06.002. Epub 2019 Jul 3.
9
Exercise, Skeletal Muscle and Circulating microRNAs.运动、骨骼肌与循环微RNA
Prog Mol Biol Transl Sci. 2015;135:471-96. doi: 10.1016/bs.pmbts.2015.07.018. Epub 2015 Aug 14.
10
Role of microRNAs in the age-related changes in skeletal muscle and diet or exercise interventions to promote healthy aging in humans.miRNAs 在骨骼肌与年龄相关变化中的作用，以及饮食或运动干预以促进人类健康衰老。
Ageing Res Rev. 2014 Sep;17:25-33. doi: 10.1016/j.arr.2014.05.001. Epub 2014 May 14.
引用本文的文献
1
Cross-sectional insights into exercise physiology knowledge among medical students in Jordan.对约旦医学生运动生理学知识的横断面洞察。
SAGE Open Med. 2024 Jan 25;12:20503121241226608. doi: 10.1177/20503121241226608. eCollection 2024.
2
The effects of aerobic and anaerobic exercises on circulating soluble-Klotho and IGF-I in young and elderly adults and in CAD patients.有氧运动和无氧运动对年轻人、老年人及冠心病患者循环可溶性α-klotho蛋白和胰岛素样生长因子-I的影响。
J Circ Biomark. 2017 Sep 28;6:1849454417733388. doi: 10.1177/1849454417733388. eCollection 2017 Jan-Dec.
3
Quantitative genomics of voluntary exercise in mice: transcriptional analysis and mapping of expression QTL in muscle.小鼠自主运动的定量基因组学：肌肉中转录分析及表达数量性状基因座定位
Physiol Genomics. 2014 Aug 15;46(16):593-601. doi: 10.1152/physiolgenomics.00023.2014. Epub 2014 Jun 17.
4
Correlations of SELE and SELP genetic polymorphisms with myocardial infarction risk: a meta-analysis and meta-regression.SELE和SELP基因多态性与心肌梗死风险的相关性：一项荟萃分析和荟萃回归分析
Mol Biol Rep. 2014 Jul;41(7):4521-32. doi: 10.1007/s11033-014-3323-2. Epub 2014 Mar 18.
5
Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle.时间进程分析揭示了人类骨骼肌适应短期有氧运动训练的基因特异性转录和蛋白质动力学。
PLoS One. 2013 Sep 12;8(9):e74098. doi: 10.1371/journal.pone.0074098. eCollection 2013.
本文引用的文献
1
Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals.健康个体剧烈运动期间循环祖细胞的时相性动员。
J Appl Physiol (1985). 2009 Dec;107(6):1943-50. doi: 10.1152/japplphysiol.00532.2009. Epub 2009 Oct 1.
2
Effects of exercise training on mobilization and functional activity of blood-derived progenitor cells in patients with acute myocardial infarction.运动训练对急性心肌梗死患者血液源性祖细胞动员及功能活性的影响。
Eur J Med Res. 2009 Sep 1;14(9):393-405. doi: 10.1186/2047-783x-14-9-393.
3
Exercise protects the cardiovascular system: effects beyond traditional risk factors.运动对心血管系统的保护作用：超越传统危险因素的影响。
J Physiol. 2009 Dec 1;587(Pt 23):5551-8. doi: 10.1113/jphysiol.2009.179432. Epub 2009 Sep 7.
4
Lack of adequate appreciation of physical exercise's complexities can pre-empt appropriate design and interpretation in scientific discovery.对体育锻炼复杂性缺乏充分认识，可能会妨碍科学发现中适当的设计和解释。
J Physiol. 2009 Dec 1;587(Pt 23):5527-39. doi: 10.1113/jphysiol.2009.179507. Epub 2009 Sep 1.
5
Relationship between circulating progenitor cells, vascular function and oxidative stress with long-term training and short-term detraining in older men.衰老男性长期训练和短期停训与循环祖细胞、血管功能和氧化应激的关系。
Clin Sci (Lond). 2010 Feb;118(4):303-11. doi: 10.1042/CS20090253.
6
alpha-actinin-3 and performance.α-辅肌动蛋白-3与运动表现。
Med Sport Sci. 2009;54:88-101. doi: 10.1159/000235698. Epub 2009 Aug 17.
7
High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats.高脂饮食诱导的肥胖改变了大鼠瘦素启动子的甲基化模式。
J Physiol Biochem. 2009 Mar;65(1):1-9. doi: 10.1007/BF03165964.
8
Mortality and longevity of elite athletes.优秀运动员的死亡率和寿命。
J Sci Med Sport. 2010 Jul;13(4):410-6. doi: 10.1016/j.jsams.2009.04.010. Epub 2009 Jul 1.
9
Commentary: Informatics in biomedicine and health care.评论：生物医学与医疗保健中的信息学
Acad Med. 2009 Jul;84(7):818-20. doi: 10.1097/ACM.0b013e3181a81f94.
10
(micro)Genomic medicine: microRNAs as therapeutics and biomarkers.（微）基因组医学：作为治疗手段和生物标志物的微小RNA
RNA Biol. 2009 Jul-Aug;6(3):324-8. doi: 10.4161/rna.6.3.8871. Epub 2009 Jul 29.
Zotero 插件