Departamento de Patologia, Universidade Federal de Sao Paulo, São Paulo, Brazil.
Clin Oral Investig. 2011 Jun;15(3):357-60. doi: 10.1007/s00784-010-0402-1. Epub 2010 Mar 25.
The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated buccal mucosa cells from individuals following digital lateral radiography. A total of 30 healthy patients (15 men and 15 women) indicated to the orthodontic therapy were submitted to digital lateral X-ray. Exfoliated oral mucosa cells were collected immediately before the X-ray exposure and after 10 days. The results pointed out no significant statistically differences (p > 0.05) of micronucleated oral mucosa cells. On the other hand, X-ray was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis, and karyolysis. In summary, these data indicate that exposure to digital lateral radiography may not be a factor that induced chromosomal damage, but it is able to promote cytotoxicity.
本研究旨在评估数字化侧位放射摄影后个体脱落的口腔颊黏膜细胞中的 DNA 损伤（微核）和细胞死亡（固缩、核溶解和核碎裂）。共有 30 名健康患者（15 名男性和 15 名女性）表示需要正畸治疗，他们接受了数字化侧位 X 射线检查。在接受 X 射线照射前和 10 天后收集脱落的口腔黏膜细胞。结果显示，微核口腔黏膜细胞无显著统计学差异（p>0.05）。另一方面，X 射线能够增加与细胞毒性密切相关的其他核改变，如核碎裂、固缩和核溶解。总之，这些数据表明，数字化侧位放射摄影的暴露可能不是引起染色体损伤的因素，但它能够促进细胞毒性。
