Departament of Pathology, Paulista Medical School, Federal University of São Paulo, UNIFESP, SP, Brazil.
Dentomaxillofac Radiol. 2010 Jul;39(5):295-9. doi: 10.1259/dmfr/17573156.
The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from adults following cone beam CT exposure.
A total of 19 healthy adults (10 men and 9 women) submitted to cone beam CT were included.
No significant statistically differences (P > 0.05) in micronucleus frequency were seen before and after cone beam CT exposure. In contrast, the tomography was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis (P < 0.05).
In summary, these data indicate that cone beam CT may not be a factor that induces chromosomal damage, but it is able to promote cytotoxicity.
本研究旨在评估成年人在接受锥形束 CT 照射后，脱落的口腔颊黏膜细胞中的 DNA 损伤（微核）和细胞死亡（固缩、核溶解和核碎裂）。
共纳入 19 名健康成年人（10 名男性和 9 名女性）进行锥形束 CT 检查。
锥形束 CT 暴露前后微核频率无显著统计学差异（P > 0.05）。相比之下，锥形束 CT 能够增加其他与细胞毒性密切相关的核改变，如核碎裂、固缩和核溶解（P < 0.05）。
总之，这些数据表明锥形束 CT 可能不是引起染色体损伤的因素，但它能够促进细胞毒性。
