State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
J Biomed Mater Res B Appl Biomater. 2010 Jul;94(1):72-9. doi: 10.1002/jbm.b.31625.
A novel injectable bone cement based on mineralized collagen was reported in this paper. The cement was fabricated by introducing calcium sulfate hemihydrate (CaSO(4).1/2H(2)O, CSH) into nano-hydroxyapatite/collagen (nHAC). The workability, in vitro degradation, in vitro and in vivo biocompatibility of the cement (nHAC/CSH) were studied. The comparative tests via in vitro and in vivo showed that the nHAC/CSH composite cement processed better biocompatibiltiy than that of pure CSH cement. The results implied that this new injectable cement should be very promising for bone repair.
本文报道了一种基于矿化胶原的新型可注射骨水泥。该水泥是通过将半水硫酸钙（CaSO4.1/2H2O，CSH）引入纳米羟基磷灰石/胶原（nHAC）中来制备的。研究了水泥（nHAC/CSH）的工作性、体外降解、体外和体内生物相容性。通过体外和体内的对比试验表明，nHAC/CSH 复合水泥的生物相容性优于纯 CSH 水泥。结果表明，这种新型可注射水泥有望用于骨修复。
