来自鹰不泊的波罗烷二萜。

Dolabellane diterpenoids from Aglaia odorata.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.

出版信息

Phytochemistry. 2010 Jun;71(8-9):1020-4. doi: 10.1016/j.phytochem.2010.03.005. Epub 2010 Mar 24.

DOI:10.1016/j.phytochem.2010.03.005

PMID:20338601

Abstract

Dolabellane diterpenoids, (1R,3E,7E,10S,11S,12R)-dolabella-3,7-dien-10,18-diol (1), (1R,3S,7E,11S,12R)-dolabella-4(16),7-dien-3,18-diol (2), (1R,7E,11S,12R)-18-hydroxydolabella-4(16),7-dien-3-one (3), (1R,3S,4S,7E,11S,12R)-3,4-epoxydolabella-7-en-18-ol (4), and (1R,3R,7E,11S,12R)-dolabella-4(16),7,18-trien-3-ol (5), were obtained from the ornamental plant Aglaia odorata. Their structures were characterized on the basis of spectroscopic analyses and further confirmed by X-ray diffraction. Compounds 1 and 5 showed weak cytotoxicity against the human myeloid leukemia HL-60, hepatocellular carcinoma SMMC-7721, and lung cancer A-549 cells.

摘要

多贝拉烷二萜类化合物 (1R,3E,7E,10S,11S,12R)-多贝拉-3,7-二烯-10,18-二醇 (1)、(1R,3S,7E,11S,12R)-多贝拉-4(16),7-二烯-3,18-二醇 (2)、(1R,7E,11S,12R)-18-羟基多贝拉-4(16),7-二烯-3-酮 (3)、(1R,3S,4S,7E,11S,12R)-3,4-环氧多贝拉-7-烯-18-醇 (4) 和 (1R,3R,7E,11S,12R)-多贝拉-4(16),7,18-三烯-3-醇 (5)，从观赏植物 Aglaia odorata 中分离得到。它们的结构基于光谱分析确定，并通过 X 射线衍射进一步证实。化合物 1 和 5 对人髓性白血病 HL-60、肝癌 SMMC-7721 和肺癌 A-549 细胞表现出较弱的细胞毒性。