State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Phytochemistry. 2010 Jun;71(8-9):1020-4. doi: 10.1016/j.phytochem.2010.03.005. Epub 2010 Mar 24.
Dolabellane diterpenoids, (1R,3E,7E,10S,11S,12R)-dolabella-3,7-dien-10,18-diol (1), (1R,3S,7E,11S,12R)-dolabella-4(16),7-dien-3,18-diol (2), (1R,7E,11S,12R)-18-hydroxydolabella-4(16),7-dien-3-one (3), (1R,3S,4S,7E,11S,12R)-3,4-epoxydolabella-7-en-18-ol (4), and (1R,3R,7E,11S,12R)-dolabella-4(16),7,18-trien-3-ol (5), were obtained from the ornamental plant Aglaia odorata. Their structures were characterized on the basis of spectroscopic analyses and further confirmed by X-ray diffraction. Compounds 1 and 5 showed weak cytotoxicity against the human myeloid leukemia HL-60, hepatocellular carcinoma SMMC-7721, and lung cancer A-549 cells.
多贝拉烷二萜类化合物 (1R,3E,7E,10S,11S,12R)-多贝拉-3,7-二烯-10,18-二醇 (1)、(1R,3S,7E,11S,12R)-多贝拉-4(16),7-二烯-3,18-二醇 (2)、(1R,7E,11S,12R)-18-羟基多贝拉-4(16),7-二烯-3-酮 (3)、(1R,3S,4S,7E,11S,12R)-3,4-环氧多贝拉-7-烯-18-醇 (4) 和 (1R,3R,7E,11S,12R)-多贝拉-4(16),7,18-三烯-3-醇 (5)，从观赏植物 Aglaia odorata 中分离得到。它们的结构基于光谱分析确定，并通过 X 射线衍射进一步证实。化合物 1 和 5 对人髓性白血病 HL-60、肝癌 SMMC-7721 和肺癌 A-549 细胞表现出较弱的细胞毒性。
