Departments of Pediatrics and of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
J Virol. 2010 Mar;84(6):3127-30. doi: 10.1128/JVI.02184-09. Epub 2009 Dec 30.
The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo.
2009 年甲型 H1N1 流感病毒的血凝素蛋白与 1918 年流感大流行病毒具有序列同源性。我们发现，人源单克隆抗体识别 1918 年和 2009 年血凝素头部结构域上的 Sa 抗原表位，该表位由于免疫选择而高度变异。这些抗体在体外对 2009 病毒具有高效价，其中一种抗体在体内表现出显著的治疗效果。
